Department of Pathology and Experimental Cancer Research, Semmelweis University, 1083 Budapest, Hungary.
Int J Mol Sci. 2023 Oct 10;24(20):15042. doi: 10.3390/ijms242015042.
Resiniferatoxin (RTX) is an ultrapotent capsaicin analog with a unique spectrum of pharmacological actions. The therapeutic window of RTX is broad, allowing for the full desensitization of pain perception and neurogenic inflammation without causing unacceptable side effects. Intravesical RTX was shown to restore continence in a subset of patients with idiopathic and neurogenic detrusor overactivity. RTX can also ablate sensory neurons as a "molecular scalpel" to achieve permanent analgesia. This targeted (intrathecal or epidural) RTX therapy holds great promise in cancer pain management. Intra-articular RTX is undergoing clinical trials to treat moderate-to-severe knee pain in patients with osteoarthritis. Similar targeted approaches may be useful in the management of post-operative pain or pain associated with severe burn injuries. The current state of this field is reviewed, from preclinical studies through veterinary medicine to clinical trials.
树脂毒素 (RTX) 是一种超强效的辣椒素类似物，具有独特的药理学作用谱。RTX 的治疗窗很宽，允许完全脱敏疼痛感知和神经源性炎症，而不会引起不可接受的副作用。研究表明，膀胱内 RTX 可恢复特发性和神经源性逼尿肌过度活动患者的尿控。RTX 还可以作为“分子手术刀”消融感觉神经元，以实现永久性镇痛。这种靶向（鞘内或硬膜外）RTX 治疗在癌症疼痛管理方面具有巨大的潜力。关节内 RTX 正在进行临床试验，以治疗骨关节炎患者的中重度膝关节疼痛。类似的靶向方法可能对术后疼痛或严重烧伤相关疼痛的管理有用。本文从临床前研究到兽医医学再到临床试验，综述了这一领域的现状。
