I.O.S.U.D., George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 540139 Targu Mures, Romania.
Department of Surgery M3, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 540139 Targu Mures, Romania.
Int J Mol Sci. 2023 Oct 23;24(20):15470. doi: 10.3390/ijms242015470.
Aortic dissection (AD) is a critical cardiovascular condition with the potential for devastating consequences. This study evaluated the histological changes in the aorta wall in patients with AD and aortic aneurysm (AA) who received surgical aortic replacement. Histopathological data showed that modifications of the media layer ( = 0.0197), myxomatous aspect ( = 0.0001), and subendothelial layer degeneration ( = 0.0107) were more frequently seen in AA versus AD samples. Patients with AA were approximately twice as likely to develop histological changes than those with AD ( = 0.0037). Patients with moderate or severe medial degeneration had a higher chance of developing AD ( = 0.0001). Because the histopathological score proved to be a predictor of both in-hospital and overall mortality, its evaluation should become the standard of care in any patients who undergo aortic replacement. Individualized postoperative management might be influenced by the histopathological aspect of the aortic layer.
主动脉夹层 (AD) 是一种严重的心血管疾病，可能会产生严重的后果。本研究评估了接受主动脉置换手术的 AD 和主动脉瘤 (AA) 患者主动脉壁的组织学变化。组织病理学数据显示，AA 样本中中膜层的改变（=0.0197）、黏液样外观（=0.0001）和内皮下层退化（=0.0107）更为常见。与 AD 相比，AA 患者发生组织学变化的可能性大约是其两倍（=0.0037）。中膜中度或重度变性的患者发生 AD 的可能性更高（=0.0001）。由于组织病理学评分被证明是住院和总死亡率的预测因子，因此其评估应成为任何接受主动脉置换的患者的标准治疗方法。术后个体化管理可能会受到主动脉层组织学方面的影响。
