The Steve and Cindy Rasmussen Institute for Genomic Medicine, Nationwide Children Hospital, Columbus, OH 43205, USA.
Institute of Molecular Biology and Biotechnology, The University of Lahore, Lahore 54590, Pakistan.
Genes (Basel). 2023 Sep 23;14(10):1849. doi: 10.3390/genes14101849.
Ewing's sarcoma is a rare type of cancer that forms in bones and soft tissues in the body, affecting mostly children and young adults. Current treatments for ES are limited to chemotherapy and/or radiation, followed by surgery. Recently, microRNAs have shown favourable results as latent diagnostic and prognostic biomarkers in various cancers. Furthermore, microRNAs have shown to be a good therapeutic agent due to their involvement in the dysregulation of various molecular pathways linked to tumour progression, invasion, angiogenesis, and metastasis. In this review, comprehensive data mining was employed to explore various microRNAs that might have therapeutic potential as target molecules in the treatment of ES.
尤因氏肉瘤是一种罕见的癌症，形成于体内的骨骼和软组织中，主要影响儿童和青少年。目前 ES 的治疗方法仅限于化疗和/或放疗，然后是手术。最近，microRNAs 作为各种癌症中潜在的诊断和预后生物标志物，显示出良好的结果。此外，microRNAs 由于参与与肿瘤进展、侵袭、血管生成和转移相关的各种分子途径的失调，因此作为一种良好的治疗剂。在这篇综述中，采用了全面的数据挖掘来探索各种 microRNAs，它们可能具有治疗潜力，作为 ES 治疗的靶分子。
