Jankowski Peter, Findeklee Sebastian, Georgescu Mihai-Teodor, Sima Romina Marina, Nigdelis Meletios P, Solomayer Erich-Franz, Klamminger Gilbert Georg, Hamoud Bashar Haj
Department for Gynecology, Obstetrics and Reproductive Medicine, Saarland University Hospital, 66421 Homburg, Germany.
Department of Oncology, "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Life (Basel). 2023 Sep 27;13(10):1973. doi: 10.3390/life13101973.
(1) Background: Surgical-oncological treatment methods are continuously put to the test in times of evidence-based medicine-notably, a constant reevaluation remains key, especially for tumor entities with increasing incidence such as vulvar carcinoma. (2) Methods: In order to determine the postoperative clinical course of different methods of vulvar excision (vulvectomy, hemivulvectomy) as well as inguinal lymph node removal (lymphadenectomy, sentinel lymph node biopsy) with regard to postoperative wound-healingprocess, perioperative hemorrhage, and re-resection rates, we retrospectively analyzed surgical, morphological and laboratory data of 76 patients with a pathological diagnosed vulvar cancer. (3) Results: Analysis of our data from a single center revealed a comparable perioperative clinical course regardless of the chosen method of vulvar excision and inguinal lymph node removal. (4) Conclusions: Thus, our results emphasize the current multimodality in surgical therapy of vulvar carcinoma, in which consideration of known prognostic factors together with the individual patient's clinical situation allow guideline-based therapy aimed at maximizing surgical safety.
(1) 背景：在循证医学时代，外科肿瘤治疗方法不断接受检验——值得注意的是，持续重新评估仍然是关键，尤其是对于外阴癌等发病率不断上升的肿瘤实体。(2) 方法：为了确定不同外阴切除方法（外阴切除术、半外阴切除术）以及腹股沟淋巴结清扫术（淋巴结清扫术、前哨淋巴结活检）在术后伤口愈合过程、围手术期出血和再次切除率方面的术后临床过程，我们回顾性分析了76例经病理诊断为外阴癌患者的手术、形态学和实验室数据。(3) 结果：我们来自单一中心的数据分析显示，无论选择何种外阴切除方法和腹股沟淋巴结清扫方法，围手术期临床过程具有可比性。(4) 结论：因此，我们的结果强调了当前外阴癌手术治疗的多模式性，其中考虑已知的预后因素以及个体患者的临床情况可实现基于指南的治疗，旨在最大限度地提高手术安全性。
