Institute of Cancer and Genomic Sciences, College of Dental and Medical School, University of Birmingham, Edgbaston, UK.
Department of Obstetrics and Gynaecology, Birmingham City Hospital, Sandwell and West Birmingham Hospitals NHS Trust, Birmingham, UK.
BJOG. 2017 May;124(6):946-954. doi: 10.1111/1471-0528.14560. Epub 2017 Mar 9.
Squamous cell carcinoma of the vulva is predominantly a disease of the elderly, where the mainstay of treatment is radical surgery. Local vulval recurrence (LVR) is a significant problem for these patients, and the rates of recurrence have not improved over the last three decades. Disappointingly, we still lack an understanding of how LVRs develop, and the best approach to prevent and manage the condition. This review discusses recent insights into the key prognostic factors that influence the risk of recurrence, focusing on the role of tumour-adjacent non-neoplastic epithelial disorders, which are thought to play a causative role.
A review that discusses the key prognostic factors that influence local recurrence in vulval cancer.
外阴鳞癌主要发生于老年患者，其主要治疗方法为根治性手术。局部外阴复发（LVR）是这些患者面临的重大问题，而且近三十年来，复发率并未改善。令人失望的是，我们仍然不了解 LVR 的发展机制，以及预防和处理该疾病的最佳方法。这篇综述讨论了近期对外阴癌中影响复发风险的关键预后因素的深入了解，重点探讨了相邻非肿瘤性上皮疾病的作用，这些疾病被认为具有致病作用。
本文综述了影响外阴癌局部复发的关键预后因素。
