Romo-Cordero Alejandro, González-Sierra Marta, Quevedo-Abeledo Juan Carlos, Quevedo-Rodríguez Adrián, Gómez-Bernal Fuensanta, de Vera-González Antonia, López-Mejías Raquel, Jiménez-Sosa Alejandro, Martín-González Candelaria, González-Gay Miguel Ángel, Ferraz-Amaro Iván
Division of Internal Medicine, Hospital Universitario de Canarias, 38320 Tenerife, Spain.
Division of Hospitalization-at-Home, Hospital Universitario de Canarias, 38320 Tenerife, Spain.
Life (Basel). 2023 Sep 29;13(10):1995. doi: 10.3390/life13101995.
The monocytes to high-density lipoprotein (HDL)-cholesterol ratio (MHR) indicates inflammation based on the anti-inflammatory properties of HDL-cholesterol as well as the pro-inflammatory effect of monocytes. Several studies have investigated MHR in various disorders, specifically in cardiovascular diseases. Consequently, MHR has been significantly associated with cardiovascular and all-cause mortality in the general population, regardless of established risk factors. However, its role in the augmented risk of cardiovascular disease found in rheumatoid arthritis (RA) has not been studied to date. This is a cross-sectional study that encompassed 430 patients with RA and 208 controls matched by sex and age. Complete blood cell count and complete lipid profile were evaluated. Multivariable analysis was made to analyze the relationship between MHR and RA disease and features subclinical carotid atherosclerosis, and traditional CV factors including insulin resistance and beta cell function indices. MHR values did not differ between controls and patients after multivariable adjustment (12 ± 6 vs. 11 ± 6, = 0.18). No relationship between this ratio and the characteristics of the disease was found excluding ESR, which showed a significant and positive association with MHR after adjustment for covariates. MHR significantly correlated with Systematic Coronary Risk Evaluation-2 (SCORE2) cardiovascular risk algorithm, and insulin resistance and beta cell function parameters after adjustment. In conclusion, MHR does not differ between patients with RA and controls. The relationship of this biomarker with disease-related data is poor. However, MHR is highly and positively related to cardiovascular risk and insulin resistance in RA.
单核细胞与高密度脂蛋白（HDL）-胆固醇比值（MHR）基于HDL-胆固醇的抗炎特性以及单核细胞的促炎作用来指示炎症。多项研究已在各种疾病中，特别是在心血管疾病中，对MHR进行了调查。因此，在普通人群中，无论是否存在既定的风险因素，MHR都与心血管疾病和全因死亡率显著相关。然而，迄今为止，其在类风湿关节炎（RA）患者心血管疾病风险增加中所起的作用尚未得到研究。这是一项横断面研究，纳入了430例RA患者和208例年龄和性别相匹配的对照。评估了全血细胞计数和完整的血脂谱。进行多变量分析以分析MHR与RA疾病、亚临床颈动脉粥样硬化特征以及包括胰岛素抵抗和β细胞功能指标在内的传统心血管因素之间的关系。多变量调整后，对照组和患者的MHR值无差异（12±6 vs. 11±6，P = 0.18）。除血沉（ESR）外，未发现该比值与疾病特征之间存在关联，在对协变量进行调整后，ESR与MHR呈显著正相关。调整后，MHR与系统性冠状动脉风险评估-2（SCORE2）心血管风险算法、胰岛素抵抗和β细胞功能参数显著相关。总之，RA患者和对照组的MHR无差异。这种生物标志物与疾病相关数据之间的关系较差。然而，MHR与RA患者的心血管风险和胰岛素抵抗高度正相关。
