Hu Xiangrong, Suzuki Tatsuya
Department of Nuclear Technology, Nagaoka University of Technology, Nagaoka, Niigata 940-2188, Japan.
Materials (Basel). 2023 Oct 16;16(20):6713. doi: 10.3390/ma16206713.
Technetium-99m(Tc) is used worldwide in 85% of nuclear medicine diagnostic imaging procedures. We developed porous MoO pellets as an alternative to reactor-based targets in an (n,γ) reaction for producing Technetium-99m (Tc) in nuclear medicine. The pellets, formed through a manufacturing process involving mixing, sintering, eluting, and drying, offer advantages such as selective dissolution and improved yield. This research offers a potential solution for stable Tc production, focusing on porous molybdenum dioxide (MoO) as a target material due to its insolubility in water. Using potassium molybdate (KMoO) as a pore former, we developed porous MoO pellets that facilitate efficient technetium extraction and target recycling. This approach offers control over pore formation and shows promise in addressing supply challenges and enhancing Tc production.
锝-99m（Tc）在全球85%的核医学诊断成像程序中得到应用。我们开发了多孔氧化钼颗粒，作为基于反应堆的靶材的替代品，用于在核医学中通过（n，γ）反应生产锝-99m（Tc）。这些颗粒通过包括混合、烧结、洗脱和干燥的制造过程形成，具有选择性溶解和提高产率等优点。本研究提供了一种稳定生产锝的潜在解决方案，由于其不溶于水，重点关注多孔二氧化钼（MoO）作为靶材。使用钼酸钾（KMoO）作为造孔剂，我们开发了多孔氧化钼颗粒，有助于高效提取锝并实现靶材回收利用。这种方法能够控制孔的形成，在应对供应挑战和提高锝产量方面显示出前景。
