Krska J, Addison G M, Soni S D
Ann Clin Biochem. 1986 May;23 ( Pt 3):340-5. doi: 10.1177/000456328602300316.
A radioreceptor assay for chlorpromazine in serum, which is based on binding to dopamine receptors, is described. This method has been postulated to measure all active metabolites as well as the parent drug. We have compared this method with an HPLC method for chlorpromazine. Dopamine-blocking activity, measured in serum samples from schizophrenic patients receiving chlorpromazine, was 1.85-9.1 times higher than serum chlorpromazine level measured by HPLC. The correlation between the two methods was 0.75. Dopamine-blocking activity was related more closely to dose of drug and to serum prolactin level than was serum chlorpromazine level measured by HPLC.
本文描述了一种基于与多巴胺受体结合的血清中氯丙嗪放射受体测定法。该方法被认为可测定所有活性代谢物以及母体药物。我们已将此方法与氯丙嗪的高效液相色谱法进行了比较。在接受氯丙嗪治疗的精神分裂症患者的血清样本中测得的多巴胺阻断活性，比高效液相色谱法测得的血清氯丙嗪水平高1.85 - 9.1倍。两种方法之间的相关性为0.75。与高效液相色谱法测得的血清氯丙嗪水平相比，多巴胺阻断活性与药物剂量和血清催乳素水平的关系更为密切。
