Stanley M, Wazer D
Neuropsychobiology. 1983;10(2-3):108-10. doi: 10.1159/000117995.
Plasma samples from individuals treated with equivalent doses of metoclopramide or thioridazine were tested for their potency in the radioreceptor assay. Samples of plasma from patients treated with thioridazine actively displaced 3H-spiroperidol from striatal membranes, while plasma from patients treated with metoclopramide were virtually inactive. The lack of activity in the radioreceptor assay is of particular interest as the concentration of metoclopramide determined by gas chromatography, in the same plasma samples, indicates a mean value of 1,102 ng/ml.
对接受等效剂量甲氧氯普胺或硫利达嗪治疗的个体的血浆样本进行了放射受体分析，以检测其效力。接受硫利达嗪治疗的患者的血浆样本能有效地将纹状体膜中的3H-螺哌啶醇置换出来，而接受甲氧氯普胺治疗的患者的血浆实际上没有活性。鉴于在相同血浆样本中通过气相色谱法测定的甲氧氯普胺浓度显示平均值为1102 ng/ml，放射受体分析中缺乏活性这一点尤其令人关注。
