Department of Respiratory and Sleep Medicine, Department of Internal Medicine, School of Medicine, The University of Jordan, Amman 11942, Jordan.
Faculty of Medicine, The University of Jordan, Amman 11942, Jordan.
Viruses. 2023 Sep 22;15(10):1975. doi: 10.3390/v15101975.
Before the COVID-19 pandemic, respiratory pathogens such as influenza, parainfluenza, and respiratory syncytial virus were the most commonly detected viruses among hospitalized patients with respiratory tract infections.
This was a retrospective observational study of inpatients and outpatients who attended Jordan University Hospital and underwent Nasopharyngeal Aspiration (NPA) in the periods from December 2017 to December 2018 and from December 2021 to December 2022. The results of multiplex respiratory pathogen real-time PCR tests for nasopharyngeal swab specimens were extracted from the electronic-based molecular diagnostic laboratory record of JUH. We compared the prevalence of the detected viruses as well as the patients' characteristics and outcomes between the two periods.
The total number of included patients was 695. Our analysis showed that a higher percentage of patients with hypertension and diabetes presented before the pandemic compared to the same period after it (-value < 0.001). The need for O2 devices, white blood cell counts, diastolic blood pressure, and the length of hospital stay were significantly higher among patients who presented before the pandemic (-value < 0.050). Influenza H1N1 (8.70% vs. 4.03%), influenza B (1.67% vs. 0.25%), parainfluenza (1.00% vs. 0.00%), human metapneumovirus (5.35% vs. 0.76%), adenoviruses (6.35% vs. 3.02%), and coronaviruses (8.70% vs. 3.53%) were detected with higher frequency in the period before the pandemic (-value = 0.011, 0.045, 0.045, 0.000, 0.035, 0.004). These results were similar in terms of changes in the detection rates of viruses after matching the number of tested patients between the periods before and after the pandemic.
We have demonstrated a reduction in the detection of several viruses, which might be due to the increase in public awareness toward infection protection measures after the COVID-19 pandemic.
在 COVID-19 大流行之前，流感、副流感和呼吸道合胞病毒等呼吸道病原体是住院呼吸道感染患者中最常检测到的病毒。
这是一项回顾性观察性研究，纳入了 2017 年 12 月至 2018 年和 2021 年 12 月至 2022 年期间在约旦大学医院就诊并接受鼻咽抽吸（NPA）的住院患者和门诊患者。从 JUH 的基于电子的分子诊断实验室记录中提取鼻咽拭子标本的多重呼吸道病原体实时 PCR 检测结果。我们比较了这两个时期检测到的病毒的流行率以及患者的特征和结局。
纳入患者总数为 695 例。我们的分析表明，与大流行后同期相比，大流行前有更高比例的高血压和糖尿病患者（-值<0.001）。大流行前就诊的患者需要氧气设备、白细胞计数、舒张压和住院时间均显著较高（-值<0.050）。大流行前流感 H1N1（8.70%比 4.03%）、流感 B（1.67%比 0.25%）、副流感（1.00%比 0.00%）、人偏肺病毒（5.35%比 0.76%）、腺病毒（6.35%比 3.02%）和冠状病毒（8.70%比 3.53%）的检出率更高（-值=0.011、0.045、0.045、0.000、0.035、0.004）。在匹配大流行前后检测患者数量后，这些病毒的检出率变化情况相似。
我们已经证明，几种病毒的检出率有所下降，这可能是由于 COVID-19 大流行后公众对感染防护措施的认识提高所致。
