Liu Ying, Chen Dong, Li Junfeng, Wang Wei, Han Rongfeng, Cui Shanshan, Bao Suqing
Endocrinology Department, Tianjin First Central Hospital, Nankai University, Tianjin 300192, China.
Graduate School, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing 100010, China.
Vaccines (Basel). 2023 Sep 30;11(10):1554. doi: 10.3390/vaccines11101554.
Coronavirus disease 2019 (COVID-19) and metabolic syndrome (MetS) are currently highly prevalent diseases worldwide. Studies on clinical outcomes of patients with Omicron and MetS, especially after vaccination with an inactivated vaccine are limited. Herein, we explored the relationship between MetS and the outcome of Omicron infection.
This was a retrospective observational study.
This study recruited 316 individuals with Omicron infection. The inpatient data from between 8 January and 7 February 2022 were obtained from designated isolation hospitals in Tianjin, China. Hierarchical and multivariable analysis was conducted on age, gender, number of complications, and vaccination status.
Among the 316 study participants, 35.1% were diagnosed with MetS. The results showed that MetS was strongly associated with Intensive Unit Care (ICU) admission, Polymerase Chain Reaction (PCR) re-positivity, and severe COVID-19. The ICU admission rates of the unvaccinated individuals, those who received two-dose and full vaccination (3 doses), were 66.7%, 19.2%, and 0, respectively ( < 0.01). Two-dose and three-dose vaccinations significantly reduced PCR re-positivity.
In summary, MetS increases the risk of ICU admission, PCR re-positivity, and severe COVID-19. MetS is a composite predictor of poor outcomes of Omicron infection. Two shots of inactivated vaccine, specifically three doses, effectively protect against Omicron even in the high-risk group.
2019冠状病毒病（COVID-19）和代谢综合征（MetS）是目前全球高度流行的疾病。关于奥密克戎毒株感染合并代谢综合征患者临床结局的研究，尤其是接种灭活疫苗后的研究有限。在此，我们探讨了代谢综合征与奥密克戎感染结局之间的关系。
这是一项回顾性观察研究。
本研究招募了316例奥密克戎感染患者。住院数据来自2022年1月8日至2月7日中国天津指定的隔离医院。对年龄、性别、并发症数量和疫苗接种状况进行分层和多变量分析。
在316名研究参与者中，35.1%被诊断为代谢综合征。结果显示，代谢综合征与重症监护病房（ICU）收治、聚合酶链反应（PCR）复阳以及重症COVID-19密切相关。未接种疫苗者、接种两剂和全程接种（3剂）者的ICU收治率分别为66.7%、19.2%和0（<0.01）。两剂和三剂疫苗接种显著降低了PCR复阳率。
综上所述，代谢综合征增加了ICU收治、PCR复阳和重症COVID-19风险。代谢综合征是奥密克戎感染不良结局的综合预测指标。两剂灭活疫苗，尤其是三剂，即使在高危人群中也能有效预防奥密克戎。
