Faculty of Veterinary Medicine, Department of Pathobiology, Ferdowsi University of Mashhad, Mashhad, Iran.
Vet Med Sci. 2023 Nov;9(6):2796-2799. doi: 10.1002/vms3.1313. Epub 2023 Oct 28.
Congenital goitre is a deadly thyroid metabolic disorder characterised by low thyroid hormone levels, subsequent secretion of excess Thyroid-Stimulating Hormone (TSH) from the pituitary gland, and compensatory thyroid gland hyperplasia. This study aimed to summarise the clinical and pathological features of congenital goitre in a goat kid. In April 2019, a dead female goat kid with a history of dystocia was referred to Ferdowsi University of Mashhad Veterinary Teaching Hospital, Mashhad, Iran, to examine the carcass and find the reason for death. The necropsy were performed, along with histopathology examination, and clinical signs were recorded. Examination of the foetus revealed the presence of an enlarged thyroid gland, and the skin was thick with myxedema, pale, and without hair. After cutting the skin, the swelling showed a significantly enlarged thyroid gland with two asymmetrical lobes, with the right lobe 3.9×7.1 cm and the left 3.7×7.5 cm in size. In the histopathological examination, a severe proliferation of follicular cells was observed, which caused the thyroid gland to be microscopically dense. In conclusion, this study highlights the importance of recognising and addressing congenital goitre in goat kids. To prevent such tragic outcomes, it is crucial to focus on early detection and intervention. Furthermore, the agents of goitre need to find out and be clear.
先天性甲状腺肿是一种致命的甲状腺代谢紊乱,其特征是甲状腺激素水平低,随后垂体分泌过多的促甲状腺激素(TSH),以及甲状腺代偿性增生。本研究旨在总结山羊先天性甲状腺肿的临床和病理特征。2019 年 4 月,一头有难产史的死亡雌性山羊幼崽被送到伊朗马什哈德 Ferdowsi 大学兽医教学医院进行剖检,以检查尸体并找出死亡原因。进行了剖检,并进行了组织病理学检查,记录了临床症状。对胎儿的检查显示甲状腺肿大,皮肤厚而有黏液水肿,苍白,没有毛发。切开皮肤后,肿胀显示出明显增大的甲状腺,有两个不对称的叶,右侧 3.9×7.1cm,左侧 3.7×7.5cm。组织病理学检查发现,滤泡细胞严重增生,导致甲状腺镜下密集。总之,本研究强调了在山羊幼崽中识别和处理先天性甲状腺肿的重要性。为了防止这种悲惨的结果,早期发现和干预至关重要。此外,还需要找出并明确甲状腺肿的原因。