Functional Architecture of Memory Department, Leibniz Institute for Neurobiology, Magdeburg, Germany.
Functional Architecture of Memory Department, Leibniz Institute for Neurobiology, Magdeburg, Germany.
Cell Rep. 2023 Nov 28;42(11):113317. doi: 10.1016/j.celrep.2023.113317. Epub 2023 Oct 26.
Why some of us remember events more clearly than others and why memory loses precision over time is a major focus in memory research. Here, we show that the recruitment of specific neuroanatomical pathways within the medial temporal lobe (MTL) of the brain defines the precision of the memory recalled over the lifespan. Using optogenetics, neuronal activity mapping, and studying recent to very remote memories, we report that the hippocampal subfield CA1 is necessary for retrieving the gist of events and receives maximal support from MTL cortical areas (MEC, LEC, PER, and POR) for recalling the most remote memories. In contrast, reduction of CA3's activity alone coincides with the loss of memory precision over time. We propose that a shift between specific MTL subnetworks over time might be a fundamental mechanism of memory consolidation.
为什么我们有些人比其他人更能清晰地记住事件，以及为什么记忆的准确性会随着时间的推移而降低，这是记忆研究的一个主要焦点。在这里，我们表明，大脑内侧颞叶（MTL）中特定神经解剖途径的募集定义了一生中回忆记忆的准确性。我们使用光遗传学、神经元活动映射和研究最近到非常遥远的记忆，报告说海马亚区 CA1 对于回忆事件的主旨是必要的，并且从 MTL 皮质区域（MEC、LEC、PER 和 POR）获得最大的支持，以回忆最遥远的记忆。相比之下，仅降低 CA3 的活动与随时间推移记忆准确性的丧失相一致。我们提出，特定 MTL 子网之间随时间的转移可能是记忆巩固的基本机制。
