Salim S, Farquharson J, Arneil G C, Cockburn F, Forbes G I, Logan R W, Sherlock J C, Wilson T S
Arch Dis Child. 1986 Nov;61(11):1068-75. doi: 10.1136/adc.61.11.1068.
Plasma concentrations of copper and zinc and leucocyte concentrations of zinc were measured in mothers during later pregnancy, at delivery, and 8-10 weeks after birth, and plasma concentrations of copper and zinc were measured in their infants at delivery and 8-10 weeks after birth. The 145 infants were either breast fed or fed one of two milk formulas supplying copper at different concentrations. None of the infants achieved the minimum copper intakes recommended by the World Health Organisation (WHO). At 2 months of age there were no major differences in growth or health detected in infants fed the different copper intakes. Infant birth weight correlated well with the ratio of maternal venous plasma zinc:maternal leucocyte zinc at delivery. Maternal venous plasma copper and zinc concentrations at birth correlated with umbilical venous plasma copper and zinc concentrations. Infants fed the higher copper content formulas had a low mean plasma zinc concentration without a significant increase in the mean plasma copper concentration. The present WHO recommendations regarding minimum copper intakes for infants fed formulas cannot be achieved with currently available formulas and are probably wrong.
在母亲妊娠晚期、分娩时以及产后8 - 10周测量其血浆铜和锌浓度以及白细胞锌浓度，并在其婴儿分娩时和产后8 - 10周测量血浆铜和锌浓度。145名婴儿要么母乳喂养，要么喂食两种不同铜浓度的配方奶之一。没有婴儿达到世界卫生组织（WHO）推荐的最低铜摄入量。在2个月大时，喂食不同铜摄入量的婴儿在生长或健康方面未发现重大差异。婴儿出生体重与母亲分娩时静脉血浆锌：母亲白细胞锌的比率密切相关。母亲分娩时静脉血浆铜和锌浓度与脐静脉血浆铜和锌浓度相关。喂食较高铜含量配方奶的婴儿平均血浆锌浓度较低，而平均血浆铜浓度没有显著增加。目前WHO关于喂食配方奶婴儿最低铜摄入量的建议无法通过现有配方奶实现，可能是错误的。
