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近年来 O-连接糖肽和糖蛋白的化学合成进展:探索生物领域的先进合成工具。

Recent advances in chemical synthesis of O-linked glycopeptides and glycoproteins: An advanced synthetic tool for exploring the biological realm.

机构信息

Center for Chemical Glycobiology, Frontiers Science Center for Transformative Molecules, School of Chemistry and Chemical Engineering, Zhangjiang Institute for Advanced Study, Shanghai Jiao Tong University, Shanghai 200240, China; Shenzhen Research Institute of Shanghai Jiao Tong University, Shenzhen, 518057, China.

Center for Chemical Glycobiology, Frontiers Science Center for Transformative Molecules, School of Chemistry and Chemical Engineering, Zhangjiang Institute for Advanced Study, Shanghai Jiao Tong University, Shanghai 200240, China.

出版信息

Curr Opin Chem Biol. 2023 Dec;77:102405. doi: 10.1016/j.cbpa.2023.102405. Epub 2023 Oct 26.

Abstract

Glycoproteins play crucial roles in various biological processes. To investigate the relationship between glycan structure and function, researchers have employed various chemical methods to precisely synthesize homogeneous O-glycoproteins. This review summarizes the recent progress of their synthetic strategies, highlighting the significant advancements in this area.

摘要

糖蛋白在各种生物过程中起着至关重要的作用。为了研究糖链结构与功能之间的关系,研究人员采用了各种化学方法来精确合成均一的 O-糖蛋白。本文综述了它们的合成策略的最新进展,强调了该领域的重要进展。

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