Assistant Professor, Department Head, Department of Oral and Maxillofacial Surgery, Kırıkkale University, Kırıkkale, Turkey.
Resarch Assistant, Department of Oral and Maxillofacial Surgery, Kütahya Health Sciences University, Kütahya, Turkey.
J Oral Maxillofac Surg. 2024 Jan;82(1):56-64. doi: 10.1016/j.joms.2023.09.022. Epub 2023 Oct 5.
Corrosion products resulting from the degradation of the dental implant surface due to biological fluids and infection may accumulate in the body and lead to clinical consequences.
The primary aim of this study is to measure the accumulation of dental implant corrosion products in the human body and the secondary aim is to estimate the association between corrosion products and fatigue.
STUDY DESIGN, SETTING, SAMPLE: This study was designed as a prospective cross-sectional and was conducted with patients presenting at to the Department of Oral and Maxillofacial Surgery. The study included patients with Grade IV dental implants made of pure titanium (Ti) at the bone level and Grade V abutments composed of Ti, aluminum (Al), and vanadium (V). Individuals possessing different metallic implants and those prone to metal exposure were not included in the study. Blood and hair samples were procured from each participant and subsequently analyzed.
The predictor variable is implant exposure, and it was divided into 3 groups; Group I, patients with healthy dental implants; Group II, patients with peri-implantitis; Control Group, individuals without dental implants.
The primary outcome variables are Al, Ti, V levels in blood and hair samples and the secondary outcome variable is the fatigue questionnaire score.
Age and gender, along with the dental implant number and duration of exposure within the study groups, are utilized as covariates.
Groups were compared using the Kruskal-Wallis and Mann-Whitney U-tests. Spearman's correlation coefficient determined relationships between groups, signifying significance with P values <.05.
The sample consisted of 30 patients aged 18 to 68, with 53% being female and 47% male. The differences among the 3 groups in the median values of blood Ti, V; hair Al, Ti, V; and fatigue questionnaire scores were not statistically significant (P > .05). However, the median blood Al value was statistically higher in Group II (P < .05).
While the presence of healthy dental implants may not affect the accumulation of Al, Ti, and V within the body, patients with peri-implantitis exhibited elevated blood Al levels, possibly due to infection influencing the corrosion process.
由于生物液和感染，牙种植体表面降解产生的腐蚀产物可能会在体内积累，导致临床后果。
本研究的主要目的是测量人体中牙种植体腐蚀产物的积累，次要目的是估计腐蚀产物与疲劳之间的关系。
研究设计、地点、样本：本研究设计为前瞻性横断面研究，在口腔颌面外科就诊的患者中进行。研究包括四级骨水平纯钛（Ti）牙种植体和五级 Ti、铝（Al）和钒（V）制成的基台的患者。本研究不包括具有不同金属植入物和易受金属暴露的个体。从每个参与者中采集血液和头发样本进行分析。
预测变量是植入物暴露，分为 3 组；第 I 组，健康牙种植体患者；第 II 组，种植体周围炎患者；对照组，无牙种植体患者。
主要观察变量是血液和头发样本中的 Al、Ti、V 水平，次要观察变量是疲劳问卷评分。
年龄和性别，以及研究组中植入物数量和暴露时间，用作协变量。
使用 Kruskal-Wallis 和 Mann-Whitney U 检验比较组间差异。Spearman 相关系数确定了组间的关系，P 值<.05 表示具有统计学意义。
该样本包括 30 名 18 至 68 岁的患者，其中 53%为女性，47%为男性。三组间血液 Ti、V；头发 Al、Ti、V；疲劳问卷评分的中位数差异无统计学意义（P>.05）。然而，第 II 组的血液 Al 中位数显著较高（P<.05）。
虽然健康牙种植体的存在可能不会影响体内 Al、Ti 和 V 的积累，但种植体周围炎患者的血液 Al 水平升高，可能是由于感染影响了腐蚀过程。
