Departamento de Ciencias Farmacéuticas, Universidad Católica del Norte, Angamos 0610, Antofagasta, Chile.
Departamento de Farmacología, Instituto de Ciencias del Mar, La Habana, Cuba.
Int J Biol Macromol. 2024 Jan;254(Pt 1):127692. doi: 10.1016/j.ijbiomac.2023.127692. Epub 2023 Oct 26.
Breast cancer is the most commonly diagnosed cancer among women worldwide. The current pharmacological treatments for breast cancer have numerous adverse effects and are not always effective. Recently, the anticancer activity of modified pectins (MPs) against various types of cancers, including breast cancer, has been investigated. This systematic review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) model, including scientific articles from the last 22 years that measured the anticancer activity of MPs on breast cancer. The articles were searched in four databases with the terms: "modified pectin" and "breast cancer". Nine articles were included, five in vitro and four mixed (in vitro and in vivo). Different models and methods by which anticancer activity was measured were analyzed. All the studies reported positive results in both cell lines and in vivo murine models of breast cancer. The extracted data suggest a positive effect and provide mechanistic evidence of MPs in the treatment of breast cancer. However, as limited number of studies were included, further in vivo studies are required to obtain more conclusive preclinical evidence.
乳腺癌是全世界女性最常见的癌症。目前针对乳腺癌的药物治疗有许多副作用，而且并不总是有效。最近，改性果胶（MPs）对包括乳腺癌在内的各种癌症的抗癌活性已被研究。本系统评价按照系统评价和荟萃分析的首选报告项目（PRISMA）模型进行，包括过去 22 年中测量 MPs 对乳腺癌抗癌活性的科学文章。文章在四个数据库中以“改性果胶”和“乳腺癌”为关键词进行检索。共纳入 9 篇文章，其中 5 篇为体外研究，4 篇为混合研究（体内和体外）。分析了不同的模型和方法来测量抗癌活性。所有研究都在乳腺癌细胞系和体内小鼠模型中报告了阳性结果。提取的数据表明 MPs 对乳腺癌的治疗具有积极作用，并提供了 MPs 的机制证据。然而，由于纳入的研究数量有限，需要进一步进行体内研究以获得更具结论性的临床前证据。
