Ebong W W
Ann Rheum Dis. 1986 Nov;45(11):911-5. doi: 10.1136/ard.45.11.911.
Acute osteomyelitis comprised 78 (29.3%) of the 266 major skeletal complications seen in 207 patients with sickle cell disease in a five and a half year period. Forty eight (61.5%) of the 78 patients were under the age of 15 years, and the mean age at onset was 12 years (range 9 months to 50 years). Osteomyelitis was often multifocal (in 42% of the cases) and associated with some life threatening disorders. Salmonella accounted for 50% of the 36 organisms isolated from 32 patients with bacteriologically confirmed diagnosis. The 'best guess' antibiotic was a combination of chloramphenicol and cloxacillin. Medical treatment alone proved adequate in most cases. No deaths resulted, but 55% of the patients developed serious complications due partly to the severity of the disease and also to infection involving the epiphyses and joints.
在五年半的时间里，207例镰状细胞病患者出现了266例主要骨骼并发症，其中急性骨髓炎占78例（29.3%）。78例患者中有48例（61.5%）年龄在15岁以下，发病的平均年龄为12岁（范围为9个月至50岁）。骨髓炎常为多灶性（42%的病例），并伴有一些危及生命的病症。在32例细菌学确诊的患者中分离出36种病原体，其中沙门氏菌占50%。“最佳推测”抗生素是氯霉素和氯唑西林的组合。在大多数情况下，单独的药物治疗就已足够。没有死亡病例，但55%的患者出现了严重并发症，部分原因是疾病的严重程度，也与骨骺和关节感染有关。
