Department of Chemistry, Gobardanga Hindu College, North 24 Parganas, West Bengal, 743273, India.
Free Radic Biol Med. 2023 Nov 20;209(Pt 2):211-227. doi: 10.1016/j.freeradbiomed.2023.10.406. Epub 2023 Oct 26.
The pursuit of effective anticancer therapies has led to a burgeoning interest in the realm of redox modulation. This review provides a comprehensive exploration of the intricate mechanisms by which diverse anticancer molecules leverage redox pathways for therapeutic intervention. Redox modulation, encompassing the fine balance of oxidation-reduction processes within cells, has emerged as a pivotal player in cancer treatment. This review delves into the multifaceted mechanisms of action employed by various anticancer compounds, including small molecules and natural products, to disrupt cancer cell proliferation and survival. Beginning with an examination of the role of redox signaling in cancer development and resistance, the review highlights how aberrant redox dynamics can fuel tumorigenesis. It then meticulously dissects the strategies employed by anticancer agents to induce oxidative stress, perturb redox equilibrium, and trigger apoptosis within cancer cells. Furthermore, the review explores the challenges and potential side effects associated with redox-based treatments, along with the development of novel redox-targeted agents. In summary, this review offers a profound understanding of the dynamic interplay between redox modulation and anticancer molecules, presenting promising avenues to revolutionize cancer therapy and enhance patient outcomes.
对有效抗癌疗法的追求促使人们对氧化还原调节领域产生了浓厚的兴趣。本篇综述全面探讨了多种抗癌分子利用氧化还原途径进行治疗干预的复杂机制。氧化还原调节涵盖了细胞内氧化还原过程的精细平衡，已成为癌症治疗的关键因素。本篇综述深入研究了各种抗癌化合物（包括小分子和天然产物）的多种作用机制，这些化合物通过破坏癌细胞的增殖和存活来发挥作用。首先，本文探讨了氧化还原信号在癌症发生和耐药性中的作用，强调了异常的氧化还原动力学如何促进肿瘤发生。然后，它详细剖析了抗癌药物诱导氧化应激、破坏氧化还原平衡和触发癌细胞凋亡的策略。此外，本文还探讨了基于氧化还原的治疗方法相关的挑战和潜在副作用，以及新型氧化还原靶向药物的开发。综上所述，本篇综述深入了解了氧化还原调节与抗癌分子之间的动态相互作用，为彻底改变癌症治疗方法和提高患者治疗效果提供了有前景的途径。
