Areekul S
Ann Trop Med Parasitol. 1986 Aug;80(4):391-8. doi: 10.1080/00034983.1986.11812039.
The transcapillary escape rate and plasma clearance rate of albumin were studied in five rhesus monkeys infected with Plasmodium knowlesi in comparison with six control monkeys by using 125I-HSA as a tracer. The plasma disappearance curve of the radioactivity was followed during the first 60 minutes after injection of this labelled protein. Plasma volume was found to be significantly higher while plasma albumin concentration was significantly lower, which resulted in the non-significantly increased intravascular albumin mass in the infected group. The mean values of the transcapillary escape rate, plasma clearance rate and the outflux of albumin from the intravascular to the extravascular compartments in the infected group were found to be significantly higher than those of the control group. This indicated that there was an increased leakage of plasma albumin from the circulation into the extravascular space in rhesus monkeys infected with P. knowlesi. As both capillary effective pore area per unit path length available for restricted diffusion and the specific permeability coefficient of plasma albumin were found to be significantly increased in the infected group, therefore the increased leakage of albumin was probably due to the increased surface of capillary membrane.
以125I-人血清白蛋白（125I-HSA）为示踪剂，研究了5只感染诺氏疟原虫的恒河猴与6只对照猴的白蛋白毛细血管逃逸率和血浆清除率。注射这种标记蛋白后的前60分钟内，跟踪放射性物质的血浆消失曲线。发现感染组的血浆体积显著更高，而血浆白蛋白浓度显著更低，这导致感染组血管内白蛋白质量增加但不显著。结果发现，感染组的毛细血管逃逸率、血浆清除率以及白蛋白从血管内到血管外间隙的流出量的平均值均显著高于对照组。这表明，感染诺氏疟原虫的恒河猴血浆白蛋白从循环系统漏入血管外间隙的情况增加。由于感染组单位路径长度上可用于限制扩散的毛细血管有效孔面积以及血浆白蛋白的比通透系数均显著增加，因此白蛋白泄漏增加可能是由于毛细血管膜表面积增加所致。
