Harbin Medical University Cancer Hospital, Harbin, 150040, China.
Department of Radiotherapy, Harbin Medical University Cancer Hospital, Harbin, 150040, China.
Crit Rev Oncol Hematol. 2023 Dec;192:104192. doi: 10.1016/j.critrevonc.2023.104192. Epub 2023 Oct 28.
Cancer progression is a dynamic process of continuous evolution, in which genetic diversity and heterogeneity are generated by clonal and subclonal amplification based on random mutations. Traditional cancer treatment strategies have a great challenge, which often leads to treatment failure due to drug resistance. Integrating evolutionary dynamics into treatment regimens may be an effective way to overcome the problem of drug resistance. In particular, a potential treatment is adaptive therapy, which strategy advocates containment strategies that adjust the treatment cycles according to tumor evolution to control the growth of treatment-resistant cells. In this review, we first summarize the shortcomings of traditional tumor treatment methods in evolution and then introduce the theoretical basis and research status of adaptive therapy. By analyzing the limitations of adaptive therapy and exploring possible solutions, we can broaden people's understanding of adaptive therapy and provide new insights and strategies for tumor treatment.
癌症进展是一个连续进化的动态过程，其中基于随机突变的克隆和亚克隆扩增产生了遗传多样性和异质性。传统的癌症治疗策略面临着巨大的挑战，这往往导致治疗失败，因为药物耐药性。将进化动力学纳入治疗方案中可能是克服耐药性问题的有效方法。特别是，一种潜在的治疗方法是适应性治疗，该策略主张采用遏制策略，根据肿瘤进化调整治疗周期，以控制耐药细胞的生长。在这篇综述中，我们首先总结了传统肿瘤治疗方法在进化方面的不足，然后介绍了适应性治疗的理论基础和研究现状。通过分析适应性治疗的局限性，并探讨可能的解决方案，可以拓宽人们对适应性治疗的理解，并为肿瘤治疗提供新的思路和策略。
