Department of Cardiology, Fujian Medical Center for Cardiovascular Diseases, Fujian Institute of Coronary Heart Disease, Fujian Medical University Union Hospital, NO.29, Xinquan Road, Fuzhou City, 350001, Fujian Province, China.
Lipids Health Dis. 2023 Oct 28;22(1):184. doi: 10.1186/s12944-023-01951-8.
The pathogenetic mechanism of atherosclerotic cardiovascular diseases is associated with insulin resistance (IR), which serves as a metabolic risk factor. As a novel indication for IR, triglyceride-glucose (TyG) index may predict cardiovascular disease outcomes.
In current study, a cohort of 157 individuals with newly developed de novo lesions who received DCB angioplasty between January 2017 and May 2021 were included. The midterm follow-up clinical results consisted of the presence of vessel-oriented composite endpoint (VOCE). The baseline TyG index was divided into three groups by tertiles. This study compared various clinical characteristics and parameters among different groups during DCB angioplasty. A multivariate Cox regression model was built to investigate the potential predictors.
Higher TyG index indicated an increased risk of VOCE according to the adjusted model (HR = 4.0, 95%Cl: 1.0-15.4, P = 0.047). A non-linear correlation was uncovered between the index and VOCE from the smooth curve. Based on Kaplan-Meier curve, individuals in the highest TyG index group were more likely to develop VOCE (P < 0.05 for log-rank).
The incidence of VOCE was shown to be independently and positively correlated with an elevated TyG index in individuals with de novo coronary lesions who received DCB angioplasty.
动脉粥样硬化性心血管疾病的发病机制与胰岛素抵抗（IR）有关，IR 是一种代谢危险因素。作为 IR 的一种新的指征，三酰甘油-葡萄糖（TyG）指数可能预测心血管疾病的结局。
本研究纳入了 2017 年 1 月至 2021 年 5 月期间接受 DCB 血管成形术治疗新发的、新发病变的 157 例患者。中期随访的临床结果包括血管定向复合终点（VOCE）的存在。根据三分位数将基线 TyG 指数分为三组。本研究比较了 DCB 血管成形术中不同组之间的各种临床特征和参数。使用多变量 Cox 回归模型来探讨潜在的预测因素。
根据调整后的模型，较高的 TyG 指数提示 VOCE 的风险增加（HR=4.0，95%CI：1.0-15.4，P=0.047）。平滑曲线显示指数与 VOCE 之间存在非线性关系。根据 Kaplan-Meier 曲线，TyG 指数最高组的个体发生 VOCE 的可能性更大（对数秩检验，P<0.05）。
在接受 DCB 血管成形术治疗的新发冠状动脉病变患者中，VOCE 的发生率与 TyG 指数升高呈独立正相关。
