甘油三酯-葡萄糖指数作为心血管疾病的标志物：现状与局限性。

The Third Affiliated Hospital of Soochow University, Juqian Road, Changzhou, 213000, China.

State Key Laboratory of Cardiovascular Diseases, Fu Wai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, No 167 BeiLiShi Road, XiCheng District, Beijing, 100037, China.

Cardiovasc Diabetol. 2022 May 6;21(1):68. doi: 10.1186/s12933-022-01511-x.

The triglyceride-glucose (TyG) index has been identified as a reliable alternative biomarker of insulin resistance (IR). Recently, a considerable number of studies have provided robust statistical evidence suggesting that the TyG index is associated with the development and prognosis of cardiovascular disease (CVD). Nevertheless, the application of the TyG index as a marker of CVD has not systemically been evaluated, and even less information exists regarding the underlying mechanisms associated with CVD. To this end, in this review, we summarize the history of the use of the TyG index as a surrogate marker for IR. We aimed to highlight the application value of the TyG index for a variety of CVD types and to explore the potential limitations of using this index as a predictor for cardiovascular events to improve its application value for CVD and provide more extensive and precise supporting evidence.

三酰甘油-葡萄糖（TyG）指数已被确定为胰岛素抵抗（IR）的可靠替代生物标志物。最近，大量研究提供了强有力的统计证据表明，TyG 指数与心血管疾病（CVD）的发展和预后相关。然而，TyG 指数作为 CVD 标志物的应用尚未得到系统评估，与 CVD 相关的潜在机制的信息则更少。为此，在本综述中，我们总结了 TyG 指数作为 IR 替代标志物的使用历史。我们旨在强调 TyG 指数在各种 CVD 类型中的应用价值，并探讨使用该指数作为心血管事件预测因子的潜在局限性，以提高其在 CVD 中的应用价值，并提供更广泛和精确的支持证据。