Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Persahabatan National Respiratory Referral Hospital Jakarta, Indonesia.
Asian Pac J Cancer Prev. 2023 Oct 1;24(10):3309-3313. doi: 10.31557/APJCP.2023.24.10.3309.
This study aims to measure arsenic concentration in bronchoalveolar lavage fluid (BALF ) of newly diagnosed lung cancer and its corelation with clinical profiles.
This study is a cross-sectional study to identify arsenic levels in newly diagnosed lung cancer patients. Bronchoalveolar lavage fluid was taken during the bronchoscopy. Arsenic concentration was measured using an ICP-EOS spectrometer.
Forty-two subjects who met inclusion criteria were recruited in this study. Arsenic metals were detected among 40% of subjects with mean, highest, and lowest values are 0.38 µg/L, 0.5 µg/L, and 0.3 µg/L, respectively. There is no significant difference between arsenic level and patients' demographic and clinical data.
Arsenic was detected in BALF in majority of newly diagnosed lung cancer patients. Despite the insignificant relationship between arsenic level and patients characteristic, this results is evidence of which arsenic metal exposure in lung cancer during their lifetime and should raise public health awareness regarding mitigating the source of exposure and its potential as lung carcinogenic agent.
本研究旨在测量新诊断肺癌患者支气管肺泡灌洗液（BALF）中的砷浓度，并分析其与临床特征的相关性。
本研究为一项横断面研究，旨在确定新诊断肺癌患者的砷水平。在支气管镜检查期间采集支气管肺泡灌洗液。使用电感耦合等离子体质谱仪（ICP-EOS）测量砷浓度。
本研究共纳入了 42 名符合纳入标准的受试者。40%的受试者检测到砷金属，其平均值、最高值和最低值分别为 0.38µg/L、0.5µg/L 和 0.3µg/L。但砷水平与患者的人口统计学和临床数据之间无显著差异。
在大多数新诊断的肺癌患者的 BALF 中检测到了砷。尽管砷水平与患者特征之间无显著关系，但这一结果表明，一生中接触砷金属与肺癌有关，应提高公众对减轻接触源及其作为肺癌致癌剂的潜在危害的认识。
