Moore C, Kuhns J G, Greenberg R A
Arch Surg. 1986 Dec;121(12):1410-4. doi: 10.1001/archsurg.1986.01400120060009.
A retrospective review of records and microscopic slides was carried out on 151 patients, encompassing nine specific upper aerodigestive tract cancer sites, correlating depth of invasion with node metastases and outcome. In this preliminary descriptive study, thickness was found to be more closely related to node metastasis and to survival than was surface diameter in middle-stage tumors, particularly in tongue, floor of the mouth, buccal mucosa, gum, and soft palate sites. Thickness, depth of penetration, and bone involvement appear to represent the degree of general tumor aggressiveness better than does surface extent. A substitution of thickness measurement for surface diameter (T) in the present TNM staging system is suggested.
对151例患者的病历和显微镜载玻片进行了回顾性研究，这些患者涵盖9个特定的上消化道呼吸道癌症部位，将浸润深度与淋巴结转移及预后相关联。在这项初步描述性研究中，发现对于中期肿瘤，尤其是舌、口底、颊黏膜、牙龈和软腭部位的肿瘤，厚度比表面直径与淋巴结转移及生存率的关系更为密切。厚度、浸润深度和骨质受累情况似乎比表面范围更能体现肿瘤的总体侵袭程度。建议在目前的TNM分期系统中用厚度测量取代表面直径（T）。
