Department of General Practice, University of Oslo, Oslo, Norway
Department of Rehabilitation Science and Health Technology, Oslo Metropolitan University, Oslo, Akershus, Norway.
BMJ Open. 2023 Oct 29;13(10):e076251. doi: 10.1136/bmjopen-2023-076251.
The STORK Groruddalen cohort was set up in 2008 to explore ethnic differences in: (1) , primarily gestational diabetes (GDM) and related health issues during pregnancy and post partum, and effects of exposures on risk for type 2 diabetes, cardiovascular disease and other health issues, and (2) , overweight/obesity and effects of early life exposures.
823 women (74% of invited) were followed from gestational week (GW) 15. Data were collected from 618 fathers. In total, 59% of women and 53% of fathers had origin from non-Western countries. Maternal mean age was 29.9 years (SD 4.9), and body mass index (BMI) 25.3 kg/m (4.9). Data were obtained from 772 women (94%) at GW 28, and 662 women (80%) 14 weeks post partum. Eleven years post partum, 385 women (53% of eligible/47% of original cohort) attended, age was 42.0 years (4.8) and BMI 27.1 kg/m (5.1). We have data for 783 children at birth, and for 586 at last time point, mean age 8.6 (0.5) years, weight 30.7 (6.8) kg and length 133.9 (6.3) cm.
We collected questionnaire data from parents, clinical measurements and blood samples from mothers, and data on children's growth (mid-pregnancy to 8 years). Our biobank includes maternal blood and urine samples, biopsy material from placentas and umbilical venous cord blood. We found several clinically important differences in , with higher risk in ethnic minority groups for GDM, insulin resistance, vitamin D and iron deficiency, depressive symptoms and physical inactivity. Contrasting patterns of fetal growth and risk of overweight/thinness at preschool age were observed across ethnic groups. Maternal GDM, obesity and high gestational weight gain were associated with children's BMI trajectories.
We will examine the impact of maternal and fetal health and development during pregnancy on long-term outcomes for mothers and offspring.
Project title STORK G-2: Women and Risk of Type 2 Diabetes NCT03870724 (ClinicalTrials.gov).
STORK Groruddalen 队列成立于 2008 年，旨在探索以下方面的种族差异：（1）主要是妊娠糖尿病（GDM）和妊娠及产后相关健康问题，以及暴露对 2 型糖尿病、心血管疾病和其他健康问题风险的影响，（2）超重/肥胖和早期生活暴露的影响。
823 名女性（邀请人数的 74%）从妊娠第 15 周开始随访。从 618 名父亲处收集数据。共有 59%的女性和 53%的父亲来自非西方国家。孕妇平均年龄为 29.9 岁（标准差 4.9），体重指数（BMI）为 25.3kg/m（4.9）。在妊娠 28 周时，772 名女性（94%）和 662 名女性（80%）在产后 14 周获得了数据。产后 11 年，385 名女性（合格人数的 53%/原始队列的 47%）参加了随访，年龄为 42.0 岁（4.8），BMI 为 27.1kg/m（5.1）。我们在出生时获得了 783 名儿童的数据，在最后一次随访时获得了 586 名儿童的数据，平均年龄为 8.6（0.5）岁，体重为 30.7（6.8）kg，身高为 133.9（6.3）cm。
我们从父母那里收集了问卷调查数据，从母亲那里收集了临床测量和血液样本，并收集了儿童生长数据（妊娠中期到 8 岁）。我们的生物库包括母亲的血液和尿液样本、胎盘活检材料和脐静脉脐带血。我们发现少数族裔群体在妊娠糖尿病、胰岛素抵抗、维生素 D 和铁缺乏、抑郁症状和体力活动不足等方面存在一些临床重要差异。在不同种族群体中，胎儿生长和学龄前超重/消瘦的风险存在相反的模式。母亲妊娠糖尿病、肥胖和妊娠体重增加过多与儿童 BMI 轨迹有关。
我们将研究妊娠期间母婴健康和发育对母婴长期结局的影响。
项目标题 STORK G-2：妇女与 2 型糖尿病风险 NCT03870724（ClinicalTrials.gov）。
