母体外周血白细胞中血清叶酸的全基因组关联研究。
Epigenome-wide association study of serum folate in maternal peripheral blood leukocytes.
机构信息
Department of Endocrinology, Morbid Obesity & Preventive Medicine, Oslo University Hospital, 0424, Oslo, Norway.
Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, 0318, Oslo, Norway.
出版信息
Epigenomics. 2023 Jan;15(1):39-52. doi: 10.2217/epi-2022-0427. Epub 2023 Mar 28.
Abstract
To perform an epigenome-wide association study (EWAS) of serum folate in maternal blood. Cross-ancestry (Europeans = 302, South Asians = 161) and ancestry-specific EWAS in the EPIPREG cohort were performed, followed by methyl quantitative trait loci analysis and association with cardiometabolic phenotypes. Replication was attempted using maternal folate intake and blood methylation data from the MoBa study and verified if the findings were significant in a previous EWAS of maternal serum folate in cord blood. cg19888088 (cross-ancestry) in , cg01952260 (Europeans) and cg07077240 (South Asians) in were associated with serum folate. cg19888088 and cg01952260 were associated with diastolic blood pressure. cg07077240 was associated with variants in . The findings were not replicated and were not significant in cord blood.
摘要
进行了一项关于母体血液中血清叶酸的全基因组关联研究（EWAS）。在 EPIPREG 队列中进行了跨种族（欧洲人=302，南亚人=161）和特定种族的 EWAS，随后进行了甲基化数量性状基因座分析，并与心脏代谢表型相关联。使用 MoBa 研究中的母体叶酸摄入量和血液甲基化数据进行了复制，并验证了这些发现在前一个脐带血中母体血清叶酸的 EWAS 中是否显著。在 中，cg19888088（跨种族），在 中，cg01952260（欧洲人）和 cg07077240（南亚人）与血清叶酸相关。cg19888088 和 cg01952260 与舒张压相关。cg07077240 与 中的变异相关。这些发现没有得到复制，在脐带血中也不显著。
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