[南美出血热病毒与疫苗及抗病毒药物研发的前沿进展]

[South American Hemorrhagic Fever viruses and the cutting edge of the vaccine and antiviral development].

作者信息

Lee Meion, Koma Takaaki, Iwasaki Masaharu, Urata Shuzo

机构信息

National Research Center for the Control and Prevention of Infectious Diseases (CCPID), Nagasaki University.

Department of Cell Regulation, Graduate School of Biomedical Sciences, Nagasaki University.

出版信息

Uirusu. 2022;72(1):7-18. doi: 10.2222/jsv.72.7.

DOI:10.2222/jsv.72.7

PMID:37899233

Abstract

South American Hemorrhagic Fever is caused by the Arenavirus, which belong to the Family Arenaviridae, genus mammarenavirus, infection at South America. South American Hemorrhagic Fever includes 1. Argentinian Hemorrhagic fever caused by Junin virus, 2. Brazilian hemorrhagic fever caused by Sabia virus, 3. Venezuelan Hemorrhagic fever caused by Guanarito virus, 4. Bolivian Hemorrhagic fever caused by Machupo virus, and 5. Unassigned hemorrhagic fever caused by Chapare virus. These viruses are classified in New World (NW) Arenavirus, which is different from Old World Arenavirus (ex. Lassa virus), based on phylogeny, serology, and geographic differences. In this review, the current knowledge of the biology and the development of the vaccines and antivirals of NW Arenaviruses which cause South American Hemorrhagic Fever will be described.

摘要

南美出血热由沙粒病毒引起，该病毒属于沙粒病毒科、哺乳类沙粒病毒属，在南美洲引发感染。南美出血热包括：1. 由胡宁病毒引起的阿根廷出血热；2. 由萨比亚病毒引起的巴西出血热；3. 由瓜纳里托病毒引起的委内瑞拉出血热；4. 由马丘波病毒引起的玻利维亚出血热；5. 由查帕雷病毒引起的未分类出血热。基于系统发育、血清学和地理差异，这些病毒被归类为新大陆（NW）沙粒病毒，与旧大陆沙粒病毒（如拉沙病毒）不同。在本综述中，将描述引起南美出血热的NW沙粒病毒的生物学现状以及疫苗和抗病毒药物的研发情况。