α-氯醇芳香缩酮类似物对雄性大鼠的抗生育活性和毒性
Antifertility activity and toxicity of alpha-chlorohydrin aromatic ketal analogues in male rats.
作者信息
Brown-Woodman P D, White I G, Ridley D D
出版信息
Aust J Biol Sci. 1986;39(2):187-92. doi: 10.1071/bi9860187.
The antifertility activity and toxicity of alpha-chlorohydrin and seven aromatic ketal derivatives were investigated in male rats. At a dose of 5 mg/kg injected intraperitoneally each day for 14 days, alpha-chlorohydrin and the methoxy benzaldehyde derivative (compound 2) produced complete infertility. The benzaldehyde derivative (compound 1) was 89% effective and the other five compounds 71-25% effective. All compounds except the least effective antifertility agent, the methylbenzaldehyde derivative (compound 3), reduced the motility of sperm recovered from the epididymis. None of the compounds caused a decrease in body or testes weight but some increased adrenal weight.
研究了α-氯醇及其七种芳香缩酮衍生物对雄性大鼠的抗生育活性和毒性。每天腹腔注射剂量为5mg/kg，持续14天，α-氯醇和甲氧基苯甲醛衍生物（化合物2）导致完全不育。苯甲醛衍生物（化合物1）的有效率为89%，其他五种化合物的有效率为71%-25%。除抗生育效果最差的甲基苯甲醛衍生物（化合物3）外，所有化合物均降低了从附睾中回收的精子的活力。没有一种化合物导致体重或睾丸重量下降，但有些化合物增加了肾上腺重量。
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