Department of Infectious Diseases, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116000, P.R. China.
Administrative Department, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116000, P.R. China.
Oncol Rep. 2023 Jun;49(6). doi: 10.3892/or.2023.8550. Epub 2023 Apr 21.
The term autophagy describes a process that supports nutrient cycling and metabolic adaptation that is accomplished via multistep lysosomal degradation. These activities modulate cell, tissue and internal environment stability, and can also affect the occurrence and development of cancer. Previous studies have mostly described autophagy as having dual effects in cancer, serving to limit tumorigenesis in the early stages of cancer, but promoting tumor progression in certain types of cancer. There have been indications in recent years that microRNAs (miRNAs/miRs) and long non‑coding RNAs (lncRNAs), as types of non‑coding RNAs, play major roles in the occurrence, invasion, development and drug resistance of hepatocellular carcinoma (HCC) and in the migration of HCC cells by governing HCC cell autophagy. Therefore, understanding which miRNAs and lncRNAs play such roles and the relevant molecular mechanisms is critical. The present review highlights the significant functions of miRNAs and lncRNAs in the regulation of autophagy in HCC and the relevant mechanisms, aiming to provide novel insight into HCC therapeutics.
自噬一词描述了一种支持营养物质循环和代谢适应的过程，该过程通过多步骤溶酶体降解来实现。这些活动调节细胞、组织和内部环境的稳定性，还可以影响癌症的发生和发展。以往的研究大多描述自噬在癌症中具有双重作用，在癌症的早期阶段限制肿瘤发生，但在某些类型的癌症中促进肿瘤进展。近年来有迹象表明，微小 RNA（miRNA/miRs）和长非编码 RNA（lncRNA）作为非编码 RNA 的两种类型，通过调控肝癌细胞自噬，在肝癌的发生、侵袭、发展和耐药以及肝癌细胞迁移中发挥重要作用。因此，了解哪些 miRNA 和 lncRNA 发挥这些作用以及相关的分子机制至关重要。本综述重点介绍了 miRNA 和 lncRNA 在调控肝癌细胞自噬中的重要功能及其相关机制，旨在为肝癌治疗提供新的思路。
