Zhang Zheng, Hong Xia, Wang Feng, Ye Xin, Yao You-Dan, Yin Ying, Yang Hong-Yu
School of Stomatology, Zunyi Medical University, Zunyi 563000, Guizhou Province, China.
Department of Stomatology, Peking University Shenzhen Hospital, Shenzhen 518036, Guangdong Province, China.
World J Clin Cases. 2023 Sep 26;11(27):6653-6663. doi: 10.12998/wjcc.v11.i27.6653.
Neurofibromas are benign tumors of a neurogenic origin. If these tumors occur without any other signs of neurofibromatosis, they are classified as isolated neurofibromas. Neurofibromas in the oral cavity mostly occur within soft tissues, indicating that solitary intraosseous neurofibromas in the mandible are rare. Due to the absence of specific clinical manifestations, early diagnosis and treatment of these tumors are difficult to achieve.
A 37-year-old female patient visited our hospital due to numbness and swelling of the gums in the right lower molar area that had persisted for half a month. The patient's overall condition and intraoral examination revealed no significant abnormalities. She was initially diagnosed with a cystic lesion in the right mandible. However, after a more thorough examination, the final pathological diagnosis was confirmed to be neurofibroma. Complete tumor resection and partial removal of the right inferior alveolar nerve were performed. As of writing this report, there have been no signs of tumor recurrence for nine months following the surgery.
This case report discusses the key features that are useful for differentiating solitary intraosseous neurofibromas from other cystic lesions.
神经纤维瘤是起源于神经的良性肿瘤。如果这些肿瘤在没有任何其他神经纤维瘤病体征的情况下发生，则被归类为孤立性神经纤维瘤。口腔内的神经纤维瘤大多发生在软组织内，这表明下颌骨孤立性骨内神经纤维瘤很少见。由于缺乏特异性临床表现，这些肿瘤难以早期诊断和治疗。
一名37岁女性患者因右下磨牙区牙龈麻木和肿胀持续半个月前来我院就诊。患者的整体状况和口腔检查未发现明显异常。她最初被诊断为右下颌骨囊性病变。然而，经过更全面的检查，最终病理诊断为神经纤维瘤。进行了肿瘤完整切除及右下颌神经部分切除。截至撰写本报告时，术后9个月无肿瘤复发迹象。
本病例报告讨论了有助于将孤立性骨内神经纤维瘤与其他囊性病变相鉴别的关键特征。
