Department for Cranio- and Maxillofacial Surgery, Heinrich-Heine-University, Moorenstr 5, D-40225 Düsseldorf, Germany.
Head Face Med. 2009 Nov 13;5:24. doi: 10.1186/1746-160X-5-24.
Solitary neurofibroma is a rare benign non-odontogenic tumor. Particularly in the oral cavity, neurogenic tumors are rare, especially if they are malignant. Neurofibromas may present either as solitary lesions or as part of the generalised syndrome of neurofibromatosis or von Recklinghausen's disease of the skin. Clinically, oral neurofibromas usually appear as pediculated or sessile nodules, with slow growth and mostly without pain. The diagnosis can be confirmed by histological examination. Neurofibromas are immunopositive for the S-100 protein, indicating its neural origin. Treatment is surgical and the prognosis is excellent. For illustration a rare case of a solitary neurofibroma in the mandible is presented.
孤立性神经纤维瘤是一种罕见的良性非牙源性肿瘤。特别是在口腔中，神经源性肿瘤很少见，尤其是恶性的。神经纤维瘤可以是单发的病变，也可以是神经纤维瘤病或皮肤 von Recklinghausen 病的全身性表现的一部分。临床上，口腔神经纤维瘤通常表现为有蒂或无蒂的结节，生长缓慢，大多无疼痛。诊断可通过组织学检查确认。神经纤维瘤对 S-100 蛋白呈免疫阳性反应，表明其神经来源。治疗方法是手术，预后极佳。为说明这一点，本文介绍了一例罕见的下颌孤立性神经纤维瘤。
