Ogunlaja Tiwalade, Oni Efe, Ibeawuchi Morris, Sattar Lubna, Eshete Filagot D, Agyebinti Felix B
General Surgery, Peoples Friendship University of Russia, Moscow, RUS.
Internal Medicine, American University of Antigua, Osbourn, ATG.
Cureus. 2023 Sep 26;15(9):e45970. doi: 10.7759/cureus.45970. eCollection 2023 Sep.
Autoimmune pancreatitis (AIP) is an uncommon variant of chronic pancreatitis characterized by inflammatory changes within the pancreatic tissue triggered by autoimmune mechanisms. It is known to mimic pancreatic cancer due to its similar clinical and radiological presentations. We underline a case of a 55-year-old male who presented with weight loss, jaundice, and pruritus. Radiological imaging suggested a pancreatic mass, raising suspicion of malignancy. However, subsequent evaluation, absence of parenchymal tissue and lymphoplasmacytic cells on endoscopic ultrasound-guided biopsy, and elevated serum immunoglobulin G4 level resulted in the diagnosis of AIP. Our case emphasizes that AIP should be included in the differential diagnosis of obstructive jaundice, especially when clinical and radiological findings are inconclusive for pancreatic cancer.
自身免疫性胰腺炎（AIP）是一种罕见的慢性胰腺炎变体，其特征是由自身免疫机制引发的胰腺组织内的炎症变化。由于其相似的临床和放射学表现，它已知会模仿胰腺癌。我们强调一例55岁男性病例，该患者出现体重减轻、黄疸和瘙痒。放射学成像显示胰腺有肿块，引起了对恶性肿瘤的怀疑。然而，随后的评估、内镜超声引导下活检未发现实质组织和淋巴浆细胞，以及血清免疫球蛋白G4水平升高，最终诊断为AIP。我们的病例强调，AIP应纳入阻塞性黄疸的鉴别诊断中，尤其是当临床和放射学检查结果对胰腺癌不确定时。
