Suvvari Tarun Kumar, Godavari Sai Tejeswi, Sanapala Praveen, Panchagnula Smruthi, Godavari Sri Kruthi Alaka Nandha
Research, Squad Medicine and Research (SMR), Visakhapatnam, IND.
General Medicine, Rangaraya Medical College, Kakinada, IND.
Cureus. 2023 Apr 21;15(4):e37947. doi: 10.7759/cureus.37947. eCollection 2023 Apr.
Autoimmune pancreatitis (AIP) is a rare form of chronic pancreatitis that can be misdiagnosed as pancreatic cancer due to similar clinical and radiological findings. In this case report, we present a 49-year-old male patient who presented with obstructive jaundice and was initially diagnosed with pancreatic cancer based on imaging findings. However, the lack of definitive parenchymal tissue in the biopsy raised suspicion for an alternative diagnosis, which led to further testing and ultimately the diagnosis of AIP. The use of endoscopic ultrasonography (EUS) and fine needle biopsy (FNB) helped to obtain a tissue diagnosis and rule out malignancy. The measurement of serum IgG4 levels further supported the diagnosis of AIP. The patient was treated with glucocorticoids and showed gradual improvement, ultimately recovering from AIP. This case highlights the importance of maintaining a high level of suspicion and considering AIP as a possible diagnosis when investigating cases that mimic pancreatic cancer. Early recognition and treatment with steroids can result in a favorable outcome for patients with AIP.
自身免疫性胰腺炎（AIP）是一种罕见的慢性胰腺炎，由于其临床和影像学表现相似，可能被误诊为胰腺癌。在本病例报告中，我们介绍了一名49岁男性患者，该患者表现为梗阻性黄疸，最初根据影像学检查结果被诊断为胰腺癌。然而，活检中缺乏明确的实质组织引发了对另一种诊断的怀疑，这促使进一步检查，最终确诊为AIP。内镜超声检查（EUS）和细针穿刺活检（FNB）有助于获得组织诊断并排除恶性肿瘤。血清IgG4水平的测定进一步支持了AIP的诊断。该患者接受了糖皮质激素治疗，病情逐渐改善，最终从AIP中康复。本病例强调了在调查疑似胰腺癌的病例时保持高度怀疑并将AIP视为可能诊断的重要性。早期识别并用类固醇治疗可为AIP患者带来良好的预后。
