Ali Maghzoub M, Taha Manal M, Ahmed Anas E, Ali Suhaila, Baiti Maisa A, Alhazmi Atyaf A, Alfaifi Bushra A, Majrabi Rania Q, Khormi Nidaa Q, Hakami Alyaj A, Alqaari Rafa A, Alhasani Raffan A, Abdelwahab Siddig I
Medical Research Center, Jazan University, Jazan, SAU.
College of Medicine, Jazan University, Jazan, SAU.
Cureus. 2023 Sep 28;15(9):e46118. doi: 10.7759/cureus.46118. eCollection 2023 Sep.
Background and objective Non-adherence to psychotropic medication can aggravate an individual's illness, diminish treatment efficacy, or make patients less responsive to future therapeutic interventions. There are several scales available to measure non-adherence to medications. In this study, we aimed to measure psychotropic medication adherence and its associated factors among schizophrenic outpatients in Saudi Arabia. Methodology A cross-sectional study was conducted with a view to measuring psychotropic medication adherence and its associated factors. The Medication Adherence Rating Scale (MARS) and the Drug Attitude Inventory-10 (DAI-10) were translated into Arabic, and their internal consistency was measured. The adjusted odds ratios (AOR) were calculated using logistic regression in the IBM SPSS Statistics software version 23 (IBM Corp., Armonk, NY). Results Spearman's rho correlation indicated a negative association between DAI-10 and MARS scores (r = -0.579; p<0.05). The Arabic version of MARS was more reliable than DAI-10, as evidenced by Cronbach's alpha value. Of note, 60.20% (n = 59) of the sample demonstrated high adherence levels. The adherence level based on MARS scoring remained unaffected (p>0.05) in terms of gender, age, employment, marital status, educational level, income level, and duration of sickness. These results were obtained by using the multivariate logistic regression model; 89% of respondents reported not using psychiatric drugs given by someone else, despite the adherence rate not affecting this number. Conclusion The rate of non-adherence to psychotropic treatment was found to be high in our cohort. Hence, it is imperative to develop comprehensive intervention methods targeting the causes of non-adherence to psychiatric medication.
背景与目的 不坚持服用精神药物会加重个体病情、降低治疗效果，或使患者对未来的治疗干预反应性降低。有多种量表可用于衡量药物治疗的依从性。在本研究中，我们旨在衡量沙特阿拉伯精神分裂症门诊患者的精神药物依从性及其相关因素。
方法 进行了一项横断面研究，以衡量精神药物依从性及其相关因素。将药物依从性评定量表（MARS）和药物态度量表-10（DAI-10）翻译成阿拉伯语，并测量其内部一致性。使用IBM SPSS Statistics软件版本23（IBM公司，纽约州阿蒙克）中的逻辑回归计算调整后的优势比（AOR）。
结果 斯皮尔曼等级相关表明DAI-10与MARS评分之间呈负相关（r = -0.579；p<0.05）。如克朗巴赫α值所示，MARS阿拉伯语版本比DAI-10更可靠。值得注意的是，60.20%（n = 59）的样本表现出高依从性水平。基于MARS评分的依从性水平在性别、年龄、就业、婚姻状况、教育水平、收入水平和患病时长方面未受影响（p>0.05）。这些结果是通过多元逻辑回归模型得出的；89%的受访者报告未使用他人提供的精神科药物，尽管依从率并未影响这一数字。
结论 在我们的队列中，发现精神药物治疗的不依从率很高。因此，必须针对精神科药物不依从的原因制定全面的干预方法。
