Popp Bianca-Stephanie, Manea Marinela Minodora, Moraru Madalina Oana
Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
Clujul Med. 2014;87(2):109-12. doi: 10.15386/cjmed-292. Epub 2014 May 30.
Some of the most significant problems encountered in the treatment of schizophrenia are non-adherence to the treatment with oral neuroleptics and difficult recovery of social functioning, after its impairment by negative psychotic symptoms and the progression of the disease with episodes of remission and relapse.
This study comparatively assesses the parameters "social functioning" and "treatment adherence" in 34 outpatients diagnosed with schizophrenia at the Adult Psychiatry Clinic III and the Adult Mental Health Center of Cluj-Napoca, using the "Medication Adherence Rating Scale" (MARS) and the "Social Adaptation Self-evaluation Scale".
The two scales revealed that patients on depot medication tend to have better social functioning and social integration rates than patients for whom oral medication was prescribed. Despite the fact that most patients participating in the study had intellectual preoccupations and, to some extent, enjoyed working, 82% of them did not have a job. The percentage of those who did was higher in the cohort of patients on depot medication (63%) than in the cohort of patients for whom orally administered medication was prescribed (53%).
Treatment adherence in patients with schizophrenia is thus significantly improved by depot medication, whereas treatment effectiveness and the frequency of adverse effects are similar for the two treatment options.
精神分裂症治疗中遇到的一些最重大问题包括不坚持口服抗精神病药物治疗，以及在因阴性精神病性症状导致社会功能受损且疾病随缓解和复发发作而进展后，社会功能难以恢复。
本研究使用“药物依从性评定量表”（MARS）和“社会适应自评量表”，对克鲁日 - 纳波卡市第三成人精神病诊所及成人心理健康中心诊断为精神分裂症的34名门诊患者的“社会功能”和“治疗依从性”参数进行了比较评估。
这两个量表显示，长效药物治疗的患者比口服药物治疗的患者往往具有更好的社会功能和社会融合率。尽管参与研究的大多数患者有智力方面的关注，并且在一定程度上喜欢工作，但其中82%没有工作。长效药物治疗患者队列中有工作的比例（63%）高于口服药物治疗患者队列（53%）。
因此，长效药物治疗可显著提高精神分裂症患者的治疗依从性，而两种治疗方案的治疗效果和不良反应发生率相似。
