Tiwari Aakanksha V, Dangore-Khasbage Suwarna
Oral Medicine and Radiology, Sharad Pawar Dental College and Hospital, Datta Meghe Institute of Higher Education and Research, Wardha, IND.
Oral Medicine and Radiology, Sharad Pawar Dental College and Hospital, Datta Meghe Institute of Medical Sciences, Wardha, IND.
Cureus. 2023 Sep 28;15(9):e46121. doi: 10.7759/cureus.46121. eCollection 2023 Sep.
The COVID-19 pandemic created havoc in the whole world since 2019. It is an explosively spreading infectious disease in which the infectious agent enters the body through sneezing coughing touching etc. The primary site of infection is the respiratory system, and the various common symptoms are dry cough, fever, dyspnea, sore throat, nasal congestion, and loss of taste sensation. A majority of the patients experience diarrhea, vomiting, severe headache, and muscle pain. Many research have been undertaken to study the therapeutic implications of different elements in coronavirus infection. One such element of interest is vitamin D. There is evidence in the literature regarding the usefulness of vitamin D in severe acute respiratory distress syndrome (ARDS) and several respiratory diseases. As the site of infection in coronavirus infection is primarily the respiratory system, reviewing in detail the correlation of this vitamin with SARS-CoV-2 infection, is an area of keen interest. Thus, the aim of this article is to explore and describe in detail the relation between the two, with reference to levels of this vitamin in diagnosed subjects and a need for its supplementation in the management of coronavirus infection and also in the prevention of post-COVID-19 complications. The review concluded that Vitamin D has an immunomodulating function. Its deficiency may lead to severe respiratory illnesses including ARDS. Vitamin D levels affect the disease course in COVID-19 infection and proper blood concentration can reduce the severity of the symptoms as well as post-COVID-19 complications.
自2019年以来，新冠疫情在全球造成了严重破坏。它是一种传播迅速的传染病，传染源通过打喷嚏、咳嗽、触摸等方式进入人体。主要感染部位是呼吸系统，常见症状包括干咳、发热、呼吸困难、喉咙痛、鼻塞和味觉丧失。大多数患者会出现腹泻、呕吐、严重头痛和肌肉疼痛。人们已经进行了许多研究来探讨不同因素在冠状病毒感染中的治疗意义。其中一个备受关注的因素是维生素D。文献中有证据表明维生素D在严重急性呼吸窘迫综合征（ARDS）和几种呼吸系统疾病中具有作用。由于冠状病毒感染的主要部位是呼吸系统，详细研究这种维生素与SARS-CoV-2感染的相关性是一个备受关注的领域。因此，本文的目的是详细探讨和描述两者之间的关系，参考确诊患者体内这种维生素的水平，以及在冠状病毒感染管理和预防新冠后遗症中补充维生素D的必要性。该综述得出结论，维生素D具有免疫调节功能。其缺乏可能导致包括ARDS在内的严重呼吸系统疾病。维生素D水平会影响新冠感染的病程，适当的血液浓度可以减轻症状的严重程度以及降低新冠后遗症的发生率。
