Sen Supriya, Thomas Shawn Sam, Cherian Anish, Abraham Deepak, Hepzhibah Julie, John Reetu, Therese Marie, Reka K, Paul M J
Department of Endocrine Surgery, CMC Hospital Vellore, Vellore, 632004 Tamil Nadu India.
Department of Nuclear Medicine, CMC Hospital Vellore, Vellore, 632004 Tamil Nadu India.
Indian J Surg Oncol. 2023 Sep;14(3):609-618. doi: 10.1007/s13193-023-01720-0. Epub 2023 Feb 28.
Thyroglossal duct cyst (TDC) is a common congenital cyst with an incidence of about 7%. Thyroglossal duct cyst carcinoma (TDCC) is a rare sequel which arises from TDC and has an incidence of about 1%. As these are rare, they do not have well-defined management guidelines. The aim of this study was to analyse the clinical profile and pathological characteristics of patients with thyroglossal duct cyst carcinoma and to propose a protocol for their treatment and follow-up.
A retrospective study was done from January 2000 to December 2019. All the clinical details, imaging characteristics, treatment and histopathology were analysed.
The mean age group in our study was 37.9 years with a female preponderance. The clinical features like rapid increase in size, fixity of the lump and lymph node metastasis were not very common. Seventy-five percent of our patients who underwent imaging had suspicious characteristics. Fifty-six percent of our patients had FNAC suggestive of TDCC. Fifty percent of our patients had concomitant thyroid carcinoma. None of our patients had distant metastasis at follow-up.
TDCC is rare and a disease of young adulthood and usually has good prognosis. It may be a clinical surprise or a small lesion which can be detected with ultrasound and targeted FNAC. There is high rate of concomitant thyroid carcinoma and hence needs careful assessment. Sistrunk's procedure with total thyroidectomy either staged or simultaneously has good outcome and permits adjuvant treatment.
甲状舌管囊肿（TDC）是一种常见的先天性囊肿，发病率约为7%。甲状舌管囊肿癌（TDCC）是一种罕见的继发病变，起源于甲状舌管囊肿，发病率约为1%。由于这些情况较为罕见，它们没有明确的管理指南。本研究的目的是分析甲状舌管囊肿癌患者的临床特征和病理特征，并提出其治疗和随访方案。
进行了一项回顾性研究，时间跨度为2000年1月至2019年12月。分析了所有临床细节、影像学特征、治疗方法和组织病理学。
我们研究中的平均年龄组为37.9岁，女性占优势。肿块大小迅速增加、肿块固定和淋巴结转移等临床特征并不常见。接受影像学检查的患者中有75%具有可疑特征。我们的患者中有56%的细针穿刺抽吸活检（FNAC）提示为TDCC。我们的患者中有50%合并甲状腺癌。在随访中，我们的患者均无远处转移。
TDCC罕见，是一种青年期疾病，通常预后良好。它可能是一个临床意外情况或一个可通过超声和靶向FNAC检测到的小病变。合并甲状腺癌的发生率很高，因此需要仔细评估。分期或同时进行全甲状腺切除的Sistrunk手术效果良好，并允许进行辅助治疗。
