AiErken NiJiati, Shao Nan, Liu Yuhong, Shi Huijuan, Shi Yawei, Yuan Zhongyu, Lin Ying
Department of Breast and Thyroid Surgery, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, China.
Breast Disease Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Breast Care (Basel). 2023 Oct;18(5):390-398. doi: 10.1159/000531943. Epub 2023 Aug 29.
Dyslipidemia can promote cell proliferation, malignant transformation, metastasis, and cancer recurrence. Moreover, it could also affect immune infiltration in the tumor microenvironment. Therefore, we aimed to explore the effects of lipid levels on tumor-infiltrating lymphocytes (TILs) and prognosis in patients with triple-negative breast cancer (TNBC).
Samples from 222 patients with TNBC from July 2007 to December 2019 were obtained from the tissue specimen banks in 3 hospitals. The blood samples were used to detect the levels of lipid levels such as apolipoprotein B (Apo B), triglyceride (TG), and low-density lipoprotein cholesterol (LDL-C). The TILs in the 222 TNBC tissues were detected using hematoxylin and eosin (H&E) staining, and the relationship between the lipid levels, clinical characteristics, and prognosis was analyzed.
Among TNBC patients, the overall survival (OS) time and disease-free survival (DFS) time were lower in patients with high LDL-C levels than those with low LDL-C levels ( < 0.01, respectively). The DFS was shorter in patients with low stromal TIL (STIL) levels than those with moderate or high STIL levels ( 0.023). Multifactor Cox regression analysis showed that LDL-C level, Apo B level, and lymphocyte-predominant breast cancer were independent risk factors for OS in TNBC patients. The number of positive lymph nodes, postoperative staging, and total amount of TILs were independent risk factors for DFS in TNBC patients.
The LDL-C and STIL levels were correlated with survival and prognosis in patients with TNBC.
血脂异常可促进细胞增殖、恶性转化、转移及癌症复发。此外，它还可能影响肿瘤微环境中的免疫浸润。因此，我们旨在探讨血脂水平对三阴性乳腺癌（TNBC）患者肿瘤浸润淋巴细胞（TILs）及预后的影响。
从3家医院的组织标本库中获取2007年7月至2019年12月期间222例TNBC患者的样本。采集血样检测载脂蛋白B（Apo B）、甘油三酯（TG）和低密度脂蛋白胆固醇（LDL-C）等血脂水平。采用苏木精-伊红（H&E）染色检测222例TNBC组织中的TILs，并分析血脂水平、临床特征与预后之间的关系。
在TNBC患者中，高LDL-C水平患者的总生存期（OS）和无病生存期（DFS）均低于低LDL-C水平患者（分别为<0.01）。基质TIL（STIL）水平低的患者DFS短于STIL水平中等或高者（P=0.023）。多因素Cox回归分析显示，LDL-C水平、Apo B水平和淋巴细胞为主型乳腺癌是TNBC患者OS的独立危险因素。阳性淋巴结数量、术后分期和TILs总量是TNBC患者DFS的独立危险因素。
LDL-C和STIL水平与TNBC患者的生存及预后相关。
