Kiwumulo Henry Fenekansi, Muwonge Haruna, Ibingira Charles, Lubwama Michael, Kirabira John Baptist, Ssekitoleko Robert Tamale
Department of Medical Physiology, Biomedical Engineering Program, Makerere University, Kampala, Uganda.
Habib Medical School, Islamic University in Uganda (IUIU), Kampala, Uganda.
Front Med Technol. 2023 Oct 12;5:1250964. doi: 10.3389/fmedt.2023.1250964. eCollection 2023.
Leukemia encompasses various subtypes, each with unique characteristics and treatment approaches. The challenge lies in developing targeted therapies that can effectively address the specific genetic mutations or abnormalities associated with each subtype. Some leukemia cases may become resistant to existing treatments over time making them less susceptible to chemotherapy or other standard therapies.
Developing new treatment strategies to overcome resistance is an ongoing challenge particularly in Low and Middle Income Countries (LMICs). Computational studies using COMSOL software could provide an economical, fast and resourceful approach to the treatment of complicated cancers like leukemia.
Using COMSOL Multiphysics software, a continuous flow microfluidic device capable of delivering anti-leukemia drugs to early-stage leukemia cells has been computationally modeled using dielectrophoresis (DEP).
The cell size difference enabled the micro-particle drug attachment to the leukemia cells using hydrodynamic focusing from the dielectrophoretic force. This point of care application produced a low voltage from numerically calculated electrical field and flow speed simulations.
Therefore, such a dielectrophoretic low voltage application model can be used as a computational treatment reference for early-stage leukemia cells with an approximate size of 5 μm.
白血病包含多种亚型，每种亚型都有其独特的特征和治疗方法。挑战在于开发能够有效应对与每种亚型相关的特定基因突变或异常的靶向疗法。随着时间的推移，一些白血病病例可能会对现有治疗产生耐药性，从而降低它们对化疗或其他标准疗法的敏感性。
开发新的治疗策略以克服耐药性是一项持续存在的挑战，在低收入和中等收入国家（LMICs）尤其如此。使用COMSOL软件进行的计算研究可为白血病等复杂癌症的治疗提供一种经济、快速且资源丰富的方法。
使用COMSOL Multiphysics软件，利用介电电泳（DEP）对一种能够将抗白血病药物输送到早期白血病细胞的连续流动微流控装置进行了计算建模。
细胞大小差异使得微颗粒药物能够利用介电泳力产生的流体动力学聚焦作用附着在白血病细胞上。这种即时护理应用通过数值计算的电场和流速模拟产生了低电压。
因此，这种介电电泳低电压应用模型可作为大小约为5μm的早期白血病细胞的计算治疗参考。
