Kiwumulo Henry Fenekansi, Muwonge Haruna, Lubwama Michael, Ibingira Charles, Kirabira John Baptist, Ssekitoleko Robert Tamale, Evans Stephen
Makerere University, Kampala, Uganda.
Department of Molecular & Nanoscale Physics, University of Leeds, Leeds, UK.
J Egypt Natl Canc Inst. 2025 Jun 3;37(1):44. doi: 10.1186/s43046-025-00301-2.
Leukemia, a heterogeneous group of hematologic malignancies, poses significant challenges in terms of early diagnosis and effective treatment. Recent advancements in nanotechnology have paved the way for innovative approaches in leukemia management, with a particular focus on IONPs. This review paper explores the diverse designs of IONPs and their multifaceted applications in the diagnosis and treatment of leukemia. Focused discussions on the synergistic combination of IONPs with conventional chemotherapy, targeted drug delivery, and hyperthermia-based approaches provide insights into the evolving landscape of IONP-mediated leukemia therapy. The role of IONPs in overcoming drug resistance mechanisms and minimizing off-target effects is critically evaluated. The later review section provides an overview of the unique physical, chemical, and magnetic properties of IONPs, emphasizing their biocompatibility, tunable magnetic properties, and surface functionalization capabilities. The review finally addresses the challenges and prospects associated with the clinical translation of IONP-based diagnostic approaches. By addressing the challenges and opportunities in this burgeoning field, this paper aims to guide future research endeavors toward the development of effective and personalized nanotherapeutics for leukemia patients.
白血病是一组异质性血液系统恶性肿瘤，在早期诊断和有效治疗方面面临重大挑战。纳米技术的最新进展为白血病治疗的创新方法铺平了道路，其中对离子纳米粒子（IONPs）尤为关注。这篇综述文章探讨了IONPs的多种设计及其在白血病诊断和治疗中的多方面应用。对IONPs与传统化疗、靶向药物递送和基于热疗的方法的协同组合进行了重点讨论，为IONP介导的白血病治疗的不断发展提供了见解。对IONPs在克服耐药机制和最小化脱靶效应方面的作用进行了严格评估。后面的综述部分概述了IONPs独特的物理、化学和磁性特性，强调了它们的生物相容性、可调磁特性和表面功能化能力。综述最后讨论了基于IONP的诊断方法临床转化相关的挑战和前景。通过应对这个新兴领域的挑战和机遇，本文旨在指导未来的研究工作，以开发针对白血病患者的有效且个性化的纳米疗法。
