Cannabidiol Keeps Hippocampal Hyperactivity in Check.
作者信息
Wong Jennifer C
机构信息
Department of Human Genetics, Emory University.
出版信息
Epilepsy Curr. 2023 Jul 19;23(5):318-320. doi: 10.1177/15357597231186917. eCollection 2023 Sep-Oct.
Abstract
摘要
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本文引用的文献
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Cannabidiol modulates excitatory-inhibitory ratio to counter hippocampal hyperactivity.大麻二酚调节兴奋性与抑制性比率以对抗海马体过度活跃。
Neuron. 2023 Apr 19;111(8):1282-1300.e8. doi: 10.1016/j.neuron.2023.01.018. Epub 2023 Feb 13.
2
Heterozygous deletion of Gpr55 does not affect a hyperthermia-induced seizure, spontaneous seizures or survival in the Scn1a+/- mouse model of Dravet syndrome.杂合性缺失 Gpr55 并不影响高热诱导的癫痫发作、自发性癫痫发作或 Dravet 综合征 Scn1a+/- 小鼠模型的存活率。
PLoS One. 2023 Jan 26;18(1):e0280842. doi: 10.1371/journal.pone.0280842. eCollection 2023.
3
Possible role of hippocampal GPR55 in spatial learning and memory in rats.海马体GPR55在大鼠空间学习与记忆中的潜在作用。
Acta Neurobiol Exp (Wars). 2018;78(1):41-50.
4
Cannabidiol attenuates seizures and social deficits in a mouse model of Dravet syndrome.大麻二酚可减轻 Dravet 综合征小鼠模型的癫痫发作和社交障碍。
Proc Natl Acad Sci U S A. 2017 Oct 17;114(42):11229-11234. doi: 10.1073/pnas.1711351114. Epub 2017 Oct 2.
5
A putative lysophosphatidylinositol receptor GPR55 modulates hippocampal synaptic plasticity.一种假定的溶血磷脂酰肌醇受体 GPR55 调节海马突触可塑性。
Hippocampus. 2017 Sep;27(9):985-998. doi: 10.1002/hipo.22747. Epub 2017 Jun 27.
6
Mutations in MBOAT7, Encoding Lysophosphatidylinositol Acyltransferase I, Lead to Intellectual Disability Accompanied by Epilepsy and Autistic Features.编码溶血磷脂酰肌醇酰基转移酶I的MBOAT7基因突变导致伴有癫痫和自闭症特征的智力残疾。
Am J Hum Genet. 2016 Oct 6;99(4):912-916. doi: 10.1016/j.ajhg.2016.07.019. Epub 2016 Sep 8.
7
GPR55, a G-protein coupled receptor for lysophosphatidylinositol, plays a role in motor coordination.GPR55 是溶血磷脂酰肌醇的 G 蛋白偶联受体，在运动协调中发挥作用。
PLoS One. 2013;8(4):e60314. doi: 10.1371/journal.pone.0060314. Epub 2013 Apr 2.
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