Maire-Lepoivre E, Krupa M, Przybyslawski J, Imbert M
Behav Brain Res. 1986 Oct;22(1):53-62. doi: 10.1016/0166-4328(86)90080-x.
Behavioral tasks were used to investigate how the orbito-insular cortex (OIC) of the cat is involved in complex operations such as the orienting reaction towards a novel stimulus. Six cats were trained preoperatively on a perimetry test to assess their ability to orient the head and eyes to objects presented in restricted regions of the visual field, and on brightness, pattern and form discrimination tasks for food reward in a two-choice discrimination apparatus. Two animals then underwent unilateral chemical lesion of the OIC using injections of ibotenic acid, two others received bilateral lesions of this same area, and the remaining two cats were used as normal controls. Postoperative performance of brightness, pattern and form discrimination was normal following OIC lesions, and no lack of retention was observed. In contrast, the cats with OIC lesions had significant deficits in their visually guided behavior. The cats ignored objects presented in the monocular segment of both sides of the visual field, even after unilateral lesion, and there was an effect on the ability to attend and fixate the central preconditioned stimulus.
行为任务被用于研究猫的眶额岛叶皮质（OIC）如何参与复杂的操作，如对新异刺激的定向反应。术前对六只猫进行视野计测试训练，以评估它们将头部和眼睛转向视野受限区域中呈现的物体的能力，以及在双选辨别装置中进行亮度、图案和形状辨别任务以获取食物奖励的能力。然后，两只动物接受了使用鹅膏蕈氨酸注射的OIC单侧化学损伤，另外两只接受了该区域的双侧损伤，其余两只猫用作正常对照。OIC损伤后，亮度、图案和形状辨别的术后表现正常，未观察到记忆缺失。相比之下，患有OIC损伤的猫在视觉引导行为方面存在显著缺陷。这些猫忽略了视野两侧单眼区域中呈现的物体，即使在单侧损伤后也是如此，并且对关注和注视中央预处理刺激的能力有影响。
