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皮肌炎致死病例中心脏传导阻滞的发病机制

Pathogenesis of heart block in a fatal case of dermatomyositis.

作者信息

Behan W M, Aitchison M, Behan P O

出版信息

Br Heart J. 1986 Nov;56(5):479-82. doi: 10.1136/hrt.56.5.479.

DOI:10.1136/hrt.56.5.479
PMID:3790384
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1236898/
Abstract

Approximately 70% of patients with dermatomyositis have evidence of cardiac damage; in one third of cases this affects principally or solely the conduction tissue. In infants similar histological lesions have been associated with a maternal autoantibody, anti-Ro, that crosses the placenta and produces congenital heart block. Anti-Ro antibody was detected in a fatal case of dermatomyositis with lesions of the conduction system.

摘要

约70%的皮肌炎患者有心脏损害的证据;在三分之一的病例中,这主要或仅影响传导组织。在婴儿中,类似的组织学病变与一种可穿过胎盘并导致先天性心脏传导阻滞的母体自身抗体——抗Ro有关。在一例伴有传导系统病变的皮肌炎致死病例中检测到了抗Ro抗体。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e28/1236898/d58ca695945a/brheartj00107-0087-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e28/1236898/e582fe56a4c7/brheartj00107-0086-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e28/1236898/d58ca695945a/brheartj00107-0087-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e28/1236898/e582fe56a4c7/brheartj00107-0086-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e28/1236898/d58ca695945a/brheartj00107-0087-a.jpg

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本文引用的文献

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Antibodies to extractable nuclear antigens in 173 patients with DNA-binding positive SLE: an association between antibodies to ribonucleoprotein and Sm antigens observed by counterimmunoelectrophoresis.173例DNA结合阳性系统性红斑狼疮患者可提取核抗原抗体:对流免疫电泳观察核糖核蛋白抗体与Sm抗原抗体之间的关联
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Connective-tissue disease, antibodies to ribonucleoprotein, and congenital heart block.结缔组织病、抗核糖核蛋白抗体与先天性心脏传导阻滞。
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ECG abnormalities in polymyositis.
伴有罕见且显著并发症——窦性心动过缓的青少年皮肌炎。
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Cardiac damage in polymyositis associated with antibodies to tissue ribonucleoproteins.与抗组织核糖核蛋白抗体相关的多发性肌炎中的心脏损害。
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Humoral immune response to cardiac conducting tissue.对心脏传导组织的体液免疫反应。
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多发性肌炎中的心电图异常
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An immunohistological study of the cellular constituents of Hodgkin's disease using a monoclonal antibody panel.使用一组单克隆抗体对霍奇金病细胞成分进行的免疫组织学研究。
Histopathology. 1984 Jan;8(1):1-25. doi: 10.1111/j.1365-2559.1984.tb02318.x.
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The Ro small cytoplasmic ribonucleoproteins: identification of the antigenic protein and its binding site on the Ro RNAs.Ro小细胞质核糖核蛋白:抗原蛋白的鉴定及其在Ro RNA上的结合位点
Proc Natl Acad Sci U S A. 1984 Apr;81(7):1996-2000. doi: 10.1073/pnas.81.7.1996.
6
Cardiac abnormalities in polymyositis/dermatomyositis.多发性肌炎/皮肌炎中的心脏异常。
Semin Arthritis Rheum. 1982 Nov;12(2):208-19. doi: 10.1016/0049-0172(82)90061-0.
7
Immunological features of polymyositis/dermatomyositis.多发性肌炎/皮肌炎的免疫学特征
Springer Semin Immunopathol. 1985;8(3):267-93. doi: 10.1007/BF00197300.
8
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N Engl J Med. 1985 Jan 10;312(2):98-100. doi: 10.1056/NEJM198501103120206.
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A monoclonal antibody with selective reactivity with functionally mature human thymocytes and all peripheral human T cells.一种与功能成熟的人胸腺细胞和所有外周血人T细胞具有选择性反应性的单克隆抗体。
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