Laboratory of Bioactive Peptides, Department of Organic Chemistry, Faculty of Biochemistry and Biological Sciences, National University of the Littoral, Ciudad Universitaria UNL, 3000, Santa Fe, Argentina.
Ministry of Science, Technology and Innovation, National Scientific and Technical Research Council (CONICET), Godoy Cruz, 2290, Ciudad de Buenos Aires, Argentina.
Amino Acids. 2023 Dec;55(12):1991-1997. doi: 10.1007/s00726-023-03349-3. Epub 2023 Oct 30.
Alzheimer's disease is characterized by the presence of senile plaques composed of β-amyloid peptide (Aβ) aggregates with toxic effects that are still not fully understood. Recently, it was discovered that Aβ(1-42) fibrils possess catalytic activity on acetylcholine hydrolysis. Catalytic amyloids are an emerging and exciting field of research. In this study, we examined the catalytic activity of the fibrils formed by Aβ(1-40), the most abundant Aβ variant, on acetylcholine hydrolysis. Our findings reveal that Aβ(1-40) fibrils exhibit moderate enzymatic activity, indicating that natural peptide aggregates could serve as biocatalysts and provide new insights into the potential role of Aβ in neurological disorders.
阿尔茨海默病的特征是存在由β-淀粉样肽（Aβ）聚集物组成的老年斑，其具有毒性作用，但仍不完全了解。最近发现，Aβ（1-42）原纤维在乙酰胆碱水解中具有催化活性。催化性淀粉样蛋白是一个新兴的令人兴奋的研究领域。在这项研究中，我们研究了最丰富的 Aβ 变体 Aβ（1-40）形成的原纤维对乙酰胆碱水解的催化活性。我们的发现表明，Aβ（1-40）原纤维表现出中等的酶活性，这表明天然肽聚集物可以作为生物催化剂，并为 Aβ 在神经疾病中的潜在作用提供新的见解。
