Ferguson D J, McColm A A, Ryan D M, Acred P
Br J Exp Pathol. 1986 Oct;67(5):679-86.
The inter-relationship of the bacteria, vegetations and cardiovasculature was studied by light and electron microscopy in experimental staphylococcal endocarditis and aortitis in acute and fatal infections. A specific spatial relationship was observed with the majority of bacterial colonies located along the junction between the cardiovasculature and the overlying thrombic vegetation. The bacterial colonies within the vegetations on the ventricular and aortic walls were smaller and embedded in a thick layer of thrombus with certain colonies showing evidence of bacterial cell death. By comparison, the lesions on the aortic valve consisted of large masses of bacteria with little or no thrombic coating. The structural damage to the aortic valve appeared to be the direct result of bacterial invasion into the connective tissue of the cusp. The acute nature of the disease may be related to bacterial destruction of the aortic valve whereas the colonies within the aortic wall vegetations are probably the source of 'resistance' to antibiotic treatment.
通过光学显微镜和电子显微镜对急性致命性感染的实验性葡萄球菌性心内膜炎和主动脉炎中细菌、赘生物和心血管系统之间的相互关系进行了研究。观察到一种特定的空间关系，大多数细菌菌落位于心血管系统与覆盖其上的血栓性赘生物之间的交界处。心室壁和主动脉壁上赘生物内的细菌菌落较小，嵌入厚厚的血栓层中，某些菌落显示出细菌细胞死亡的迹象。相比之下，主动脉瓣上的病变由大量细菌组成，几乎没有或没有血栓涂层。主动脉瓣的结构损伤似乎是细菌侵入瓣叶结缔组织的直接结果。该疾病的急性性质可能与主动脉瓣的细菌破坏有关，而主动脉壁赘生物内的菌落可能是对抗生素治疗“耐药”的来源。
