Chighine Kévin, Léonce Estelle, Boutin Céline, Desvaux Hervé, Berthault Patrick
Nanosciences et Innovation pour les Matériaux, la Biomédecine et l'Energie, CEA, CNRS, Université Paris-Saclay, 91191, Gif-sur-Yvette, France.
Magn Reson (Gott). 2021 Jun 11;2(1):409-420. doi: 10.5194/mr-2-409-2021. eCollection 2021.
The availability of a benchtop nuclear magnetic resonance (NMR) spectrometer, of low cost and easily transportable, can allow detection of low quantities of biosensors, provided that hyperpolarized species are used. Here we show that the micromolar threshold can easily be reached by employing laser-polarized xenon and cage molecules reversibly hosting it. Indirect detection of caged xenon is made via chemical exchange, using ultra-fast Z spectroscopy based on spatio-temporal encoding. On this non-dedicated low-field spectrometer, several ideas are proposed to improve the signal.
一种低成本且易于运输的台式核磁共振（NMR）光谱仪的出现，只要使用超极化物质，就能够检测低含量的生物传感器。在这里我们表明，通过使用激光极化的氙气和可逆容纳它的笼状分子，可以轻松达到微摩尔阈值。通过基于时空编码的超快Z光谱法，利用化学交换对笼状氙进行间接检测。在这种非专用的低场光谱仪上，我们提出了几种提高信号的方法。
