人类参考图谱中的功能组织单元。

Functional Tissue Units in the Human Reference Atlas.

作者信息

Bidanta Supriya, Börner Katy, Herr Bruce W, Nagy Marcell, Gustilo Katherine S, Bajema Rachel, Maier Libby, Molontay Roland, Weber Griffin

机构信息

Department of Intelligent Systems Engineering, Luddy School of Informatics, Computing, and Engineering, Indiana University, Bloomington, IN 47408, USA.

Department of Stochastics, Institute of Mathematics, Budapest University of Technology and Economics, Muegyetem rkp. 3., H-1111 Budapest, Hungary.

出版信息

bioRxiv. 2023 Oct 26:2023.10.16.562593. doi: 10.1101/2023.10.16.562593.

DOI:10.1101/2023.10.16.562593

PMID:37905079

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10614912/

Abstract

Functional tissue units (FTUs) form the basic building blocks of organs and are important for understanding and modeling the healthy physiological function of the organ and changes during disease states. In this first comprehensive catalog of FTUs, we document the definition, physical dimensions, vasculature, and cellular composition of 22 anatomically correct, nested functional tissue units (FTUs) in 10 healthy human organs. The catalog includes datasets, illustrations, an interactive online FTU explorer, and a large printable poster. All data and code are freely available. This is part of a larger ongoing international effort to construct a Human Reference Atlas (HRA) of all cells in the human body.

摘要

功能组织单位（FTUs）构成了器官的基本组成部分，对于理解和模拟器官的健康生理功能以及疾病状态下的变化非常重要。在这份首个FTUs综合目录中，我们记录了10个健康人体器官中22个解剖学上正确的、嵌套的功能组织单位（FTUs）的定义、物理尺寸、脉管系统和细胞组成。该目录包括数据集、插图、交互式在线FTU浏览器以及大幅可打印海报。所有数据和代码均可免费获取。这是正在进行的一项更大规模国际努力的一部分，旨在构建人体所有细胞的人类参考图谱（HRA）。