Revela, Woburn, Massachusetts, USA.
Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts, USA.
Sci Data. 2023 Jul 19;10(1):452. doi: 10.1038/s41597-023-02018-0.
More than 150 scientists from 17 consortia are collaborating on an international project to build a Human Reference Atlas, which maps all 37 trillion cells in the healthy adult human body. The initial release of this atlas provided hierarchical lists of the anatomical structures, cell types, and biomarkers in 11 organs. Here, we describe the methods we used as part of this initiative to build the first open, computer-readable, and comprehensive database of the adult human blood vasculature, called the Human Reference Atlas-Vasculature Common Coordinate Framework (HRA-VCCF). It includes 993 vessels and their branching connections, 10 cell types, and 10 biomarkers. With this paper we are releasing additional details on vessel types and subtypes, branching sequence, anastomoses, portal systems, microvasculature, functional tissue units, mappings to regions vessels supply or drain, geometric properties of vessels, and links to 3D reference objects. Future versions will add variants and connections to the lymph vasculature; and, it will iteratively expand and improve the database as additional experimental data become available through the participating consortia.
来自 17 个联盟的 150 多名科学家正在合作开展一个国际项目，以构建人类参考图谱，绘制健康成年人身体中所有 37 万亿个细胞。该图谱的初步版本提供了 11 个器官中解剖结构、细胞类型和生物标志物的层次列表。在这里，我们描述了作为该计划的一部分用于构建第一个开放、可计算机读取和全面的成人人类血管数据库的方法，称为人类参考图谱-血管通用协调框架（HRA-VCCF）。它包括 993 条血管及其分支连接、10 种细胞类型和 10 种生物标志物。通过本文，我们将发布有关血管类型和亚型、分支序列、吻合、门系统、微血管、功能组织单位、与血管供应或引流区域的映射、血管的几何特性以及与 3D 参考对象的链接的更多详细信息。未来的版本将添加淋巴血管的变体和连接；并且，随着参与联盟的更多实验数据的出现，该数据库将迭代扩展和改进。
