The Second School of Clinical Medicine, Southern Medical University, Guangzhou, China.
Department of Dermatology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China.
Exp Dermatol. 2024 Jan;33(1):e14964. doi: 10.1111/exd.14964. Epub 2023 Oct 31.
Interleukin-17 s (IL-17s) are well-known proinflammatory cytokines, and their antagonists perform excellently in the treatment of inflammatory skin diseases such as psoriasis. However, their physiological functions have not been given sufficient attention by clinicians. IL-17s can protect the host from extracellular pathogens, maintain epithelial integrity, regulate cognitive processes and modulate adipocyte activity through distinct mechanisms. Here, we present a systematic review concerning the physiological functions of IL-17s. Our goal is not to negate the therapeutic effect of IL-17 antagonists, but to ensure their safe use and reasonably explain the possible adverse events that may occur in their application.
白细胞介素-17（IL-17）是众所周知的促炎细胞因子，其拮抗剂在治疗银屑病等炎症性皮肤病方面表现出色。然而，其生理功能尚未引起临床医生的足够重视。IL-17 可以通过不同的机制保护宿主免受细胞外病原体的侵害，维持上皮完整性，调节认知过程和调节脂肪细胞活性。在这里，我们对 IL-17 的生理功能进行了系统评价。我们的目的不是否定 IL-17 拮抗剂的治疗效果，而是确保其安全使用，并合理解释其应用中可能出现的不良反应。
